anguage representation in children with 22q11 deletion syndrome and children with Specific Language Impairment

Completed

Conditions: Language development problems
10057167

Registration Number: NL-OMON44550

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 36

Inclusion Criteria

- Age 6-10 years old
- A diagnosis of Specific Language Impairment (SLI) or 22q11DS

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Metal objects in the body that are not MRI compatible
- Anxiety in the scanner (evaluated by parent/caretaker, or after practice in mock scanner)
- Both verbal and non-verbal IQ lower than 70
- Severe hearing loss (>35 dB)
- Relevant comorbidities (i.e. severe autism)
Notably, to determine the last three parameters, the respective physician/hospital or school/institution will be asked to provide the researchers with neuropsychological/IQ test results, the results of hearing tests and relevant comorbidities. Parents/caretakers of participants will be asked for permission for this during one of the phone calls in the recruitment phase. To confirm current hearing ability, during the first visit, a tone audiogram will be made. If a recent (i.e. less than 2 years old) IQ test is not available, a new IQ test will be administered.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Similarity between 22q11DS and SLI language activation patterns and that of a<br /><br>healthy control population. In other words: do the children with 22Q11DS and<br /><br>SLI show fMRI language-activation in the same brain regions as controls? </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation between language activation parameters (e.g. language<br /><br>lateralization index, amplitude of signal changes in the language areas) and<br /><br>scores on language tasks of the children with language impairment.</p><br>