Carotid Plaque Imaging Project (CPIP)

Recruiting

• Conditions: Atherosclerosis; Atherosclerotic Plaque
• Interventions: Other: Observational study

• Registration Number: NCT05821894
• Lead Sponsor: Lund University

Brief Summary

The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-26
• Study First Submitted: 2023-03-21
• Study First Submitted QC: 2023-04-18
• Study First Posted: 2023-04-20
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-09
• Last Update Posted: 2024-10-15
• Primary Completion: 2029-12
• Study Completion: 2029-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 3500

Inclusion Criteria

• Patients older than 18 years old, male or female that are eligible for carotid endarterectomy due to atherosclerosis and that can provide informed consent.

Exclusion Criteria

• Patients younger than 18 years old that cannot provide informed consent; pregnant.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Carotid Plaque Imaging Project (CPIP)	Observational study	-

Primary Outcome Measures

Name	Time	Method
Number of participants suffering post-operative cardiovascular events (by 2025)	Follow up assessment year 2025 (recording of events occurring since 2023)	Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
Number of participants suffering post-operative cardiovascular events (by 2027)	Follow up assessment year 2027 (recording of events occurring since 2025)	Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
Number of participants suffering post-operative cardiovascular events (by 2029)	Follow up assessment year 2029 (recording of events occurring since 2027)	Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)

Trial Locations

Locations (1)

Skåne University Hospital (SUS); 🇸🇪 Malmö, Skåne, Sweden