New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques
- Conditions
- Carotid Artery Plaque
- Registration Number
- NCT03335033
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The researchers are trying to determine if the characterization of "vulnerable" carotid artery plaques can be accomplished with ultrasound-based methods that look for vessels in the plaque and measure the plaque stiffness.
- Detailed Description
All participants will receive a one time Carotid contrast-enhanced Ultrasound (CEUS) examination that may take 30-60 minutes. Follow up calls will be made to the Participants at 6, 12 ,24 and 36 months to ask about occurrence of major adverse cardiovascular events.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
- Subject has carotid plaque with > 50% stenosis
- Subject is able to understand the study procedure and provide informed consent
- Subject is pregnant or breast feeding
- Subject is unable to provide informed consent
- Subject has contraindication to the use of the Lumason contrast agent.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Number of Subjects Who Completed All of the Ultrasound Examinations 1 year after recruitment Total number of subjects who completed all of the ultrasound examinations to determine visualization of arterial wall (contrast-enhanced ultrasound, 3-D volume ultrasound) and its mechanical properties (shear wave elastography).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States
Mayo Clinic in Rochester🇺🇸Rochester, Minnesota, United States