Water and the Gastropressor Response - Tachyphylaxis
- Conditions
- Orthostatic Hypotension
- Interventions
- Other: water tiny doseOther: water high dose
- Registration Number
- NCT00580996
- Lead Sponsor
- Satish R. Raj
- Brief Summary
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.
- Detailed Description
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- orthostatic hypotension (fall in BP>20/10 mmHg)
- pressor response to water in other studies
- Age 18-80 years
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 2 water tiny dose water 1 oz in AM 1 water high dose 16 oz water in AM
- Primary Outcome Measures
Name Time Method blood pressure 2nd water intervention
- Secondary Outcome Measures
Name Time Method heart rate 2nd intervention
Trial Locations
- Locations (1)
Vanderbilt University
🇺🇸Nashville, Tennessee, United States