Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

Not Applicable

Completed

• Conditions: Fluid Challenge; Fluid Therapy; Pharmacodynamics; Fluid Responsiveness; Intravenous Fluids
• Interventions: Other: oral water; Other: saline intravenous administration

• Registration Number: NCT05153837
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-30
• Study First Submitted: 2021-11-30
• Study First Submitted QC: 2021-11-30
• Study First Posted: 2021-12-10
• Primary Completion: 2023-08-28
• Study Completion: 2023-08-28
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-01
• Last Update Posted: 2025-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• Healthy volunteer subject between 18 and 30 years old
• patient with a regular sinus rhythm
• Echogenic subject.
• Fasting of solid and liquid since 8 h
• Subject in regular sinus rhythm.
• Written consent signed.

Exclusion Criteria

• Any known cardiac, renal or endocrine pathology.
• Arrhythmia rhythm disorder by atrial fibrillation
• Pregnant or nursing woman.
• Pathology versus indicating Nacl administration.
• Person under tutors or curators or deprived of liberty.
• Person not affiliated to a social security scheme.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oral water	oral water	Experimental group: oral administration of 500 ml of water.
intravenous	saline intravenous administration	Active comparator: Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route

Primary Outcome Measures

Name	Time	Method
number of fluid responders 30 minutes after fluid expansion	30 minutes after fluid expansion

Trial Locations

Locations (1)

CHU Amiens-Picardie; 🇫🇷 Amiens, France