NL-OMON42780已完成3 期
Pharmacokinetics of escalating doses of clonidine in ICU patients - Clonidine kinetics 1.1
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* at least 18 years of age
- •* intubated
- •at the start of the study. Because of the high incidence of delirium on the ICU in all age categories, all age groups > 18 years will be included.
排除标准
- •* Severe neurotrauma,
- •* Severe dementia (living in a nursing home)
- •* Inability to speak Dutch or English, which is one of the causes of not being able to use the CAM-ICU.
- •* The use of clonidine during the 96 hours before the start of the study.
- •* Bradycardia (<50/min)
- •* Severe hypotension (MAP < 65 after volume resuscitation and vasopressors)
- •* Pregnancy and lactation (pregnancy test are routinely performed in premenopausal women on the ICU).
- •* Epilepsy
- •* Known clonidine intolerance
- •* Liver cirrhosis (Child Pugh class C)
- •* Recent and acute myocardial infarction
- •* Severe heart failure (LVEF < 30%)
- •* Second or third degree AV-block without a permanent pacemaker
- •* Expected transfer to another hospital
- •When renal failure (eGFR <30ml/min): maximum dose of clonidine will be 1200mcg
研究者
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