Analgesic Effect Of Intra-articular Dexamethasone Versus Fentanyl Added as an Adjuvant to Bupivacaine for Postoperative Pain Relief in Knee Arthroscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 87
- 试验地点
- 2
- 主要终点
- Duration of postoperative analgesia
研究概览
简要总结
However, local anesthetic agents can produce analgesia for a limited time when used as a single injection. Bupivacaine is a local anesthetic that has an immediate action on pain by blocking peripheral afferents. However, as the ideal analgesic, the drug must cover the whole postoperative period (≥ 24 hours); therefore, bupivacaine is usually combined with many adjutants to provide long-lasting post-arthroscopy analgesia.
详细描述
Intr-articular drug administration has gained popularity because of its simplicity and efficacy in achieving anesthesia for diagnostic and operative arthroscopy and for providing postoperative analgesia .although the knee joint has been examined most commonly, arthroscopy of other joints such as shoulder, ankle, wrist, metatarsophalangeal and temporomandibular joints is being increasingly used.
Intra-articular installation of local anesthesia during arthroscopic procedures has been used by many orthopedic surgeons to provide pain relief after surgery.The aim of this study was to evaluate the analgesic efficacy of intra-articular dexamethasone versus fentanyl added as an adjuvant to bupivacaine in patients undergoing knee arthroscopic surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologists physical status (ASA) I or II
排除标准
- •Contraindication to spinal anesthesia.
- •Allergy to the study drugs.
- •Refusal of the patients.
研究组 & 干预措施
Group DB/Dexamethasone-Bupivacaine
Patients were received an intra-articular injection of 8mg dexamethasone added to18mL of 0.25% bupivacaine
干预措施: Group DB/Dexamethasone-Bupivacaine (Drug)
Group FB /Fentanyl-Bupivacaine
Patients were received an intra-articular injection of 1 ug/kg fentanyl added to 18 mL of 0.25% bupivacaine
干预措施: Group FB /Fentanyl-Bupivacaine (Drug)
Group PB/Placebo-Bupivacaine
Patients were received an intra-articular injection of 2 mL isotonic saline added to 18 mL of 0.25% bupivacaine
干预措施: Group PB/Placebo-Bupivacaine (Drug)
结局指标
主要结局
Duration of postoperative analgesia
时间窗: for 24 hour after surgery
Time to the first request of pethidine in minutes within the first 24 hours postoperatively
次要结局
- Total analgesic requirement(for 24 hour after surgery)
- Mean arterial blood pressure(At 1,2,4,6,8,12,18 and 24 hours postoperatively.)
- Patients' satisfaction(for 24 hour after surgery)
- Heart rate(At 1,2,4,6,8,12,18 and 24 hours postoperatively.)
- Pain score(measured at 1,2,4,6,8,12,18 and 24 hours postoperatively.)