Can Genetic Changes Predict Weight Loss and Outcome After Bariatric Surgery and Can it Related to Virus Infection and Function of Liver and Adipose Tissue as Well as Lipid and Protein Profiles.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Karolinska Institutet
- Enrollment
- 2,000
- Locations
- 3
- Primary Endpoint
- Genetic markers
Study Overview
Brief Summary
There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •laparoscopic gastric by-pass with BMI greater than 35
Exclusion Criteria
- •unable to understand swedish
Outcomes
Primary Outcomes
Genetic markers
Time Frame: day of surgery and 1 and 2 years after surgery
Blood samples and tissue biopsies taken at the time of surgery and at follow-up.
Secondary Outcomes
- Lipid and protein patterns in plasma and tissues(day of surgery and at 1 and 2 years postoperatively)
- Genexpression and comorbid disease(At time of bariatric surgery and 1-2 years postoperatively)
- Previous viral infection(At time of surgery)
Investigators
Erik Näslund
Professor
Karolinska Institutet