Intravenous Metoprolol in Septic Shock

Phase 2

Completed

• Conditions: Septic Shock; Ventilator Acquired Pneumonia
• Interventions: Drug: Intravenous metoprolol tartrate; Other: Standard Care (in control arm)

• Registration Number: NCT06592547
• Lead Sponsor: Alexandria University

Brief Summary

A RCT designed to assess the effect of giving intravenous beta-blockers in patients with septic shock after achieving hemodynamic stability. The principle of this study is to control heart rate allowing for better diastolic filling and thus better perfusion.

Detailed Description

A RCT, conducted at alexandria main university hospital, patients were divided into 2 groups, Control group which received the standard care for septic shock and metoprolol group which recieved intravenous metoprolol then patients were assessed for Blood pressure, heart rate, iv fluids needed, vasopressor doses and 28 days mortality

Study Timeline

• Study Start: 2022-04-01
• Primary Completion: 2023-12-01
• Study First Submitted: 2024-09-10
• Study First Submitted QC: 2024-09-10
• Study First Posted: 2024-09-19
• Study Completion: 2024-11-10
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-28
• Last Update Posted: 2025-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• The study population included adult patients (≥ 18 years) diagnosed with septic shock secondary to VAP with sinus tachycardia, from April 1, 2022, to April 31, 2023. Septic shock was defined according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). VAP was identified as per the guidelines provided by the American Thoracic Society and Infectious Diseases Society of America.

Exclusion Criteria

• Patients were excluded if they had contraindications to beta-blockers, had a history of heart failure, or had been receiving beta-blockers prior to the septic shock. Patients were also excluded if they developed complications from beta- blockers administration.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Metoprolol group	Intravenous metoprolol tartrate	The group that received intravenous metoprolol
Control group	Standard Care (in control arm)	The group that received standard care

Primary Outcome Measures

Name	Time	Method
28-day Mortality	28 days

Secondary Outcome Measures

Name	Time	Method
ICU stay	28 days
ventilator days	28 days
iv fluids	28 days

Trial Locations

Locations (1)

Alexandria Main university hospital; 🇪🇬 Alexandria, Egypt