Comparing oral and intravenous paracetamol plasma levels when given as pre-medication for peri-operative analgesia
- Conditions
- Peri-operative analgesiaSurgeryPain relief
- Registration Number
- ISRCTN11248599
- Lead Sponsor
- orth Bristol NHS Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 104
1. Assessment of fitness as indicated by the American Society of Anesthesiologists (ASA) grades I and II
2. Age group 16 to 75 years
3. All patients listed for elective surgery by Mr P Robinson on a Thursday for Ear, Nose & Throat surgery
1. Patients refusing to participate in study
2. Patient unable to take an oral preparation
3. Cases shorter than one hour
4. Patients already taking a paracetamol containing drug combination, or have taken in the last 12 hours
5. Patients with a history of paracetamol allergy, hypersensitivity or previous reaction/serious adverse reaction
6. Children under the age of 16
7. Patients unable to understand or give consent to participation in the study; incapable adults, psychiatric/medical disorder able to modify patient compliance
8. Pregnant or breastfeeding
9. History of complete non-responsiveness to acetaminophen
10. Pancreatic disease in the previous 12 months
11. Impaired liver/kidney function
12. Patients that might pose an infection risk to staff due to blood products
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method