Influence of the donor-host interface on results of keratoplastic procedures currently in use in corneal surgery. A structured follow-up.

Recruiting

• Conditions: corneal transplant; 10042261

• Registration Number: NL-OMON30230
• Lead Sponsor: Oogziekenhuis Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 210

Inclusion Criteria

Group 1, PKP:
- BCVA >= 0.4 (logMAR)
- not eligible for ALTK, DALK, PLK;Group 2, ALTK:
- BCVA >= 0.4 (logMAR);Group 3, DALK:
- BCVA >= 0.4 (logMAR)
- keratoconus without hydrops or Descemet*s rupture
- stromal opacities not reaching Descemet*s membrane
- no concommitant endothelial disease;Group 4, PLK:
- BCVA >= 0.4 (logMAR)
- endothelial dysfunction caused by pseudophakic or aphakic edema
- (Fuch*s) endothelial dystrophy

Exclusion Criteria

Group 1, PKP:
- mental retardation
- previous corneal surgery ;Group 2, ALTK:
- mental retardation
- history of (penetrating) keratoplasty
- HLA-typed keratoplasty;Group 3, DALK:
- mental retardation
- history of (penetrating) keratoplasty
- HLA-typed keratoplasty;Group 4, PLK:
- mental retardation
- history of (penetrating) keratoplasty
- HLA-typed keratoplasty
- severe scarring of anterior stroma

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quantification of possible relationship between corneal reflectivity (confocal<br /><br>microscopy) and:<br /><br>- visual acuity (logMAR)<br /><br>- contrast sensitivity (Pelli Robson chart)<br /><br>- keratoplastic technique</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Quantification of possible relationship between corneal reflectivity and:<br /><br>- scatter measured by Oculus C-quant<br /><br>- pachymetry (3 methods)<br /><br>Quantification of:<br /><br>- endothelial cell density<br /><br>- quality of life </p><br>