NL-OMON41285
Recruiting
Not Applicable
The effect of a combined caloric restriction and exercise intervention on phenotypic profiles of offspring of families with exceptional longevity and their partners - Growing Old Together
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- lichaamsgewicht, lichaamssamenstelling, bloeddruk, metabole markers gerelateerd aan glucose- en vetstofwisseling
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 194
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Main study:
- •Middle\-aged (\<75years) couples consisting of offspring from long\-lived siblings and his/her current partner. In incidental cases they can participate as singles.
- •BMI \>\=23 and \<\=35 kg/m2;Validation study:
- •Middle\-aged persons (age \>\= 60 and \<\= 70\).
- •BMI \>\=23 and \<\=35 kg/m2
- •Participants must bring their own bike
Exclusion Criteria
- •Main study:
- •Type I or type II diabetes (on diabetic medication)
- •Individuals who have lost or gained \>\=3 kg over the past 6 months
- •Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work)
- •Any disease or condition that seriously affects body weight and/or body composition including active types of cancer, heart failure (NYHA III/VI), COPD (GOLD III/VI)
- •Recent (3 months prior to intervention) immobilisation for longer than 1 week
- •Psychiatric or behavioral problems (eg, history or clinical manifestation of any eating disorders, vegan dietary lifestyle, major depression)
- •Medication: thyroid medication, immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF\-alpha antagonists etc))
- •use of anticoagulantia (e.g. coumarines, carbaspirin calcium): only excluded for biopsies
- •Concurrent participation in any other intervention study or weight management program;Magnetic Resonance (MR) exclusion criteria (3 tesla and 7 tesla):
Outcomes
Primary Outcomes
Not specified
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