NL-OMON41285招募中不适用
The effect of a combined caloric restriction and exercise intervention on phenotypic profiles of offspring of families with exceptional longevity and their partners - Growing Old Together
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 194
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Main study:
- •Middle-aged (<75years) couples consisting of offspring from long-lived siblings and his/her current partner. In incidental cases they can participate as singles.
- •BMI >=23 and <=35 kg/m2;Validation study:
- •Middle-aged persons (age >= 60 and <= 70).
- •BMI >=23 and <=35 kg/m2
- •Participants must bring their own bike
排除标准
- •Main study:
- •Type I or type II diabetes (on diabetic medication)
- •Individuals who have lost or gained >=3 kg over the past 6 months
- •Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work)
- •Any disease or condition that seriously affects body weight and/or body composition including active types of cancer, heart failure (NYHA III/VI), COPD (GOLD III/VI)
- •Recent (3 months prior to intervention) immobilisation for longer than 1 week
- •Psychiatric or behavioral problems (eg, history or clinical manifestation of any eating disorders, vegan dietary lifestyle, major depression)
- •Medication: thyroid medication, immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc))
- •use of anticoagulantia (e.g. coumarines, carbaspirin calcium): only excluded for biopsies
- •Concurrent participation in any other intervention study or weight management program;Magnetic Resonance (MR) exclusion criteria (3 tesla and 7 tesla):
- •Claustrophobia
- •Pacemakers and defibrillators
- •Nerve stimulators
- •Intracranial clips
- •Intraorbital or intraocular metallic fragments
- •Cochlear implants
- •Ferromagnetic implants (e.g. thoracic implant for scoliosis)
- •Inability to lie supine during for 1 hour
- •not having a general practitioner;Validation study:
- •Any conditions that may inhibit free movement
- •Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work)
研究者
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