Effects of caloric restriction and weight loss on hypothalamic function in response to glucose ingestion in patients with type 2 diabetes mellitus.

• Conditions: 10018424; diabetes; diabetes mellitus type 2

• Registration Number: NL-OMON30633
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Male,
Body Mass Index (BMI) higher than 25 kg/m2 with a maximum of 30 kg/m2,
age 40-60 years,
Diabetes type 2

Exclusion Criteria

Impaired renal function (serum creatinine > 176 µmol/L).
Use of SU derivatives or insuline
Leg ulcers, gangrene.
Blood pressure > 160/100 mmHg with or without antihypertensive drugs.
Contra indications MRI: p.e. pacemaker, aneurism clips, metallic implants, neurostimulator, metal foreign bodies, hydrocephalus pump, claustrophobia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in reaction pattern of neuronal activity (as measured with fMRI) in the<br /><br>hypothalamus in respons to intake of glucose in patients with diabetes type 2,<br /><br>before caloric restriction and after 3 days and 6 weeks low calorie diet (i.e.<br /><br>before and after weight loss).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>