Comparative effects of high-flow nasal cannula and simple mask during deep sedatio

Not Applicable

Completed

• Conditions: Neoplasms

• Registration Number: KCT0006221
• Lead Sponsor: Asan Medical Center

Brief Summary

Intraprocedural PaO2 and the difference of pre- and intraprocedural PaO2 were significantly different between two groups. Intraprocedural PaO2 of mask groups and HFNC were 199.9 (154.3 – 224.9) and 287.0 (191.3 – 379.9) mmHg, respectively (p = 0.009) and the differences of pre- and intraprocedural PaO2 of mask groups and HFNC were, 111.6 (67.4 – 141.8) and 188.5 (100.1 – 280.3) mmHg, respectively (p = 0.009l). The incidence of hypoxic event was not significantly different between two groups. (36% of mask group vs. 25.0% of HFNC group, respectively; p = 0.505). However, the incidence of severe hypoxic event was significantly lower in HFNC group than mask group. (32% of mask group vs. 4.2% of HFNC group, p = 0.045). Intraprocedural PaO2/FiO2 were significantly different between two groups. PaO2/FiO2 of mask group was significantly higher than HFNC group [399.9 (308.6 – 449.7) and 287.0 (191.3 – 379.9) mmHg, respectively (p = 0.005)]. RR was significantly different between two groups (F = 7.944; p = 0.08). There were significant differences in patient’s satisfaction score between two groups. Patients in mask group were more satisfied than HFNC group [60.6 (56.8 – 66) vs. 54.0 (44.0 – 62.0), respectively; p =0.031].

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-12-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

1) Patients with hepatocellular carcinoma underwent monitored anesthesia care during us-guided radiofrequency ablation
2) Adult patients aged 20 to 80
3) Patients who voluntarily agreed to participate in this clinical trial
4) ASA classification 1-2

Exclusion Criteria

1) Patients who does not agree to participate in the study
2) Modified Allen's test negative
3) Patients with severe cardiovascular or cerebrovascular disease
4) Patients with severe respiratory disease
5) Inappropriate patients determined by researcher

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
partial pressure of oxygen (PaO2)

Secondary Outcome Measures

Name	Time	Method
patient satisfaction ;partial pressure of carbon dioxide (PaCO2);Incidence of hypoxia (SpO2<94%) and additional advanced airway intervention