Management of Dushta Pratishyaya w.s.r. to chronic sinusitis

Phase 2

Completed

Conditions: Patients having nasal blockage, nasal discharge, heaviness in head i.e. Chronic sinusitis

Registration Number: CTRI/2017/03/008225

Lead Sponsor: Institute for Post Graduation Teaching And Research in Ayurveda

Brief Summary: Chronic Sinusitis (CS) is a common diseaseworldwide, particularly in places with high levels of atmospheric pollution. Itsestimated prevalence ranges widely, from 2 to 16%. People who are sufferingfrom CS have experience of significant decrease in quality of life andproductivity. In modern medical science, only symptomatic relief can beprovided by the treatment and recurrence rate is very high in spite of surgicalmanagement. There are so many treatment modalities described in *Ayurvedic*text for nasal disease such as *Nasya*, *Dhoompana* etc. Number of works werecarried out on *Nasya* proving its efficacy in CS. *Dhoompana* is one of the besttherapies for diseases of Supra clavicular region specially *Vata Kapha* predominancy.Therefore, present study is designed to evaluate comparative efficacy of *Dhoomapana*in management of *Dushta Pratishyaya* (Chronic Sinusitis). Total 119 patients registered, among them 102patients have completed their course and 17 patients left the treatment due totheir personal reason. The selected patients were assigned randomly into two groups (i.e. A andB), 63 patients were assigned in group A among them 51 was completed treatment and56 patients were assigned in group B among them 51 was completed treatment. Patients of Group A were treated with *ChitrakaHaritaki Avaleha* orally (5gm BD with Luke warm water) and *Vyaghri Taila Nasya*followingby *Saraladi Dhoompana*(3sitting of 7 days with gap of 3 days). Patients of Group B weretreated with *Chitraka Haritaki Avaleha* orally (5gm BD with Luke warmwater) and *Vyaghri Taila Nasya* without *Saraladi Dhoompana* (3sitting of 7 days with gap of 3 days). After completion of the treatment, the patients werefollowed for one month at the interval of 15 days. Effect of therapy on subjectiveparametersshowedstatistically highly significant (<0.001)improvement in both groups but percentage wise better result was found in GroupA than Group B. Effect of therapy on objective parameters showed statisticallyhighly significant (p<0.001) improvement was obtained in paranasal sinusestenderness and nasal endoscopic findings in both groups. Percentage wise betterresult was obtained in Group A than Group B. Effect of therapy on radiologicalfindings showed statistically significant result (p<0.05) in right maxillaryand right frontal sinus while statistically insignificant result (p>0.05)was obtained in left maxillary and left frontal sinus in Group A While in GroupB statistically insignificant results were found in right-left Maxillary andright Frontal sinus. Overall effect of therapy showed in Group A that 74.51%,19.61% and 05.88% patients got marked, moderate and complete reliefrespectively whereas in Group B 54.90%, 41.18% and 03.92% patients gotmoderate, marked and mild relief respectively. None patients remain unchangedin both groups. Thus, overall effect of therapy showed better result in Group Athan in Group B. It canbe inferred that Group A i.e. *Chitraka Haritaki Avaleha* orally and *VyaghriTaila Nasya* along with *Dhoompana* was showing better result thanGroup B i.e. *Chitraka Haritaki Avaleha* orally and *Vyaghri Taila Nasya*without *Dhoompana* in *Dushta Pratishyaya.* **Survey study:** A questionnaire type ofsurvey study which was observational study carried out to elicit possible etiological factors of the disease *Dushta Pratishyaya* (ChronicSinusitis) and a special survey questionnaire wasconstructed for this. In survey study, cold atmosphere (79.83%), dustyatmosphere (73.94%), history of long-standing nasal infection (77.31%), indigestion(52.94%), Wet (humid) atmosphere (45.37%), habit of suppress natural urges (42.02%) were observed as etiological factors. **Microbiological study** of *ChitrakaHaritaki Avaleha* to check the sterility of *Avaleha* was done. Sampleof *Chitraka Haritaki Avaleha* was analyzed monthly during clinical study period toassess any microbial contamination at different climatic conditions andtemperature set ups. Till last date of study (i.e. drug completion time) nocontamination was found. Maximum temperature noted during study was 33Âº Cand minimum was 15Âº C whereas relative humidity was noted 93% (maximum) and 22%(minimum). Thus, it is proved that drug preparation was done according tostandard operating procedure and stored at proper humidity and temperature inair tight container at appropriate place; although having higher moisture content,*Avaleha* does not get contaminated.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 100

Inclusion Criteria

1 Patients fulfilling the diagnostic criteria based on sign and symptoms of Dushta Pratishyaya (Chronic Sinusitis) in Ayurvedic classics and modern science will be selected for the present study.
2 Patients will be include into the study irrespective of caste, religion, sex etc.

Exclusion Criteria

1 Patients below 18 and above 60 years of age.
2 Chronic debilitating disease like diabetes mellitus CA AIDS.
3 Cases which require surgical treatment.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
management of Chronic sinusitis	1 month

Secondary Outcome Measures

Name	Time	Method
Achieve normal ventilation of para-nasal sinuses	1 month

Trial Locations

Locations (1): Institute for Post Graduate Teaching and Research in Ayurveda
🇮🇳
Jamnagar, GUJARAT, India
Institute for Post Graduate Teaching and Research in Ayurveda
🇮🇳Jamnagar, GUJARAT, India
Amisha Patel
Principal investigator
9723273584
amisha.patel1311@gmail.com