Effect of Methylprednisolone in acute spinal cord injury
Phase 3
Recruiting
- Conditions
- A 48-hour regimen with methyl prednisolone in patients with acute spinal cord injuries significantly improves neurological symptoms in patients..
- Registration Number
- IRCT20190116042374N1
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
All traumatic patients with acute thoracolumbar spinal cord injury
Age over 13 years
Exclusion Criteria
Patients with nerve spinal cord injury or single injury Cauda equina
Damage after injury with bullets
Pregnant patients
Patients receiving steroids for other reasons
Patients under 13 years of age
Patients with a history of receiving 100 mg of Methylprednisolone or a diet equal to it
Diabetic patients
Patients with immunodeficiency
Patients Needing Emergency Surgery
Loss of consciousness
LP contraindications and any traumatic lesions of the brain
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The evaluation of peroxidation metabolites (TAC) total antioxidant capacity (MDA) and malondialdehyde (MDA), which indicates the inflammatory status of the spinal cord, as well as sensory and motor status assessment based on ASIA and FRANKL grading at discharge. Timepoint: Patients will undergo a re-examination and assessment of sensory and motor status in three intervals at the time of discharge (day 7-10) of the sixth week (day 42-49) and the sixth month (day 180-150)after treatment. On day 1 and 4 of admission, total antioxidant capacity and malondialdehyd (TAC and MDA)is measured. Method of measurement: The sensory and motor status of the patient is measured at each turn with the examination and total antioxidant capacity and malondialdehyd metabolites in the laboratory by the device.
- Secondary Outcome Measures
Name Time Method