Usage of Tramadol With Levobupivacaine for Pain Treatment After Cesarean Section
Phase 4
Completed
- Conditions
- Pain, Postoperative
- Interventions
- Registration Number
- NCT01916915
- Lead Sponsor
- Ufuk University
- Brief Summary
Patients experience considerable amount of pain after cesarean section. The aim of this study is to investigate the effect of tramadol (an opioid pain killer) added to levobupivacaine (a local anesthetic) in continuous wound infusion (which is done by placing a catheter in the incision) after cesarean sections.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 65
Inclusion Criteria
- Planned cesarean section
- American Society of Anesthesiologists Class I-II
Exclusion Criteria
- Patients refusing to enroll in the study
- Serious coagulopathy
- Serious systemic disease
- Story of allergy to drugs being used in the study
- Morbid obesity (Body mass index > 30)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tramadol 1 Tramadol infusion via wound catheter 1 mg/kg tramadol + 0.25% levobupivacaine 4 ml/h infusion Tramadol 2 Tramadol infusion via wound catheter 2mg/kg tramadol + 0.25% levobupivacaine 4 ml/h infusion Tramadol 1 Levobupivacaine 1 mg/kg tramadol + 0.25% levobupivacaine 4 ml/h infusion Tramadol 2 Levobupivacaine 2mg/kg tramadol + 0.25% levobupivacaine 4 ml/h infusion Levobupivacaine Levobupivacaine 0.25% levobupivacaine 4ml/h infusion
- Primary Outcome Measures
Name Time Method lowering of pain as measured by visual analogue scores forty eight hours after the operation
- Secondary Outcome Measures
Name Time Method total additional analgesic consumption forty eight hours after the operation
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie tramadol-levobupivacaine synergy in post-cesarean pain management via continuous wound infusion?
How does tramadol addition to levobupivacaine compare to standard IV opioid analgesia in postoperative cesarean pain control?
Are there specific biomarkers predicting response to tramadol-levobupivacaine wound infusion in postpartum patients?
What adverse events are associated with tramadol-levobupivacaine continuous wound infusion in NCT01916915 and how are they managed?
What alternative opioid-local anesthetic combinations show promise for post-cesarean analgesia compared to tramadol-levobupivacaine?
Trial Locations
- Locations (1)
Ufuk University Dr Rıdvan Ege Hospital
🇹🇷Ankara, Turkey