SSEP Fluctuations Due to Dexmedetomidine During Posterior Spine Fusion
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 25
- 主要终点
- SSEPs
研究概览
简要总结
Intravenous anesthetic agents as far as inhaled agents produce a dose depended increase in latency and decrease in amplitude of SomatoSensory Evoked Potential (SSEP). Dexmetedomidine, a highly selective a2 adrenergic agonist, not only minimizes the anesthetic agents but also the opioids, reducing the analgesic demands. The effect of dexmedetomidine on SSEP has not been elucidated. We aimed to investigate alterations on somatosensory SSEP in adults during posterior spinal fusion surgery before and after Dexmedetomidine administration.
详细描述
Patients 18-75 years old, ASA (physical status classification system) I-III, scheduled for elective posterior spinal fusion surgery were enrolled in this prospective study. After induction in anesthesia, it was applied SSEP monitoring and a baseline test was performed after 15min (in order to wash out the propofol used for induction). Infusion of Dexmedetomidine was started at a bolus dose of 1mcg/Kg following by 0.7mcg/Kg. Bispectral Index (BIS) monitored the depth of anesthesia and an adequate level (40-50) of anesthesia was maintained by sevoflurane. SSEP were recorded intraoperatively from the tibial nerve (P37) and data were analyzed over that period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ASA physical status 1-3
排除标准
- •Patients with ASA physical status >3,
- •Body Mass Index (BMI) over 30,
- •indication for rapid sequence induction,
- •any contraindication for receiving b-blocker,
- •Glasgow Coma Scale (GCS) <13,
- •history of drug abuse,
- •neurologic deficit or preoperatively foreseen delayed extubation,
- •preoperative heart rate<45.
研究组 & 干预措施
Dexmedetomidine
Data of SSEPs (amplitude and latency) after dexmedetomidine infusion.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
SSEPs
时间窗: 10 min after starting infusion of dexmedetomidine
measurement of SSEPs parameters regarding the baseline.
次要结局
未报告次要终点
研究者
Asouhidou Irene
Assistant Professor
George Papanicolaou Hospital