Comparing Effect of Propofol, Dexmedetomidine and Their Combination on Duration Mechanical Ventilation in Patient After Cardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Propofol
- Conditions
- Respiratory Failure
- Sponsor
- Anesthesia Research Group UA
- Enrollment
- 356
- Locations
- 1
- Primary Endpoint
- length of the mechanical ventilation
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
There is a direct relationship between the sedative agent and the duration of ventilation.
Detailed Description
Sedation and sedative agent have direct correlation to the mechanical length. As known mechanical length could increase length of the hospital stay (LOHS) and mortality rate. The right sedative agent can decrease the length go the mechanical ventilation. The goal of the research to compare 3 sedation strategies and their influence to the duration of mechanical ventilation.
Investigators
Plechysta Yelyzaveta
Chief of the anesthesia department
Anesthesia Research Group UA
Eligibility Criteria
Inclusion Criteria
- •Multi vascular lesions of the coronary arteries according to coronary angiography;
- •Heart valve damage was confirmed by, which is subject to surgical correction (aortic stenosis of III degree with a gradient on the aortic valve of more than 42 mmHg, aortic insufficiency III, mitral valve stenosis II-III, mitral regurgitation II-III)
- •Age of patients from 18-80 years; • Patient consent to participate in the study;
Exclusion Criteria
- •Refusal to participate;
- •Hypersensitivity to propofol, dexmedetomidine;
- •Prolonged mechanical ventilation in case of surgical complications (bleeding, inadequate perfusion of the myocardium);
- •Occurred ischemic stroke;
- •History of the ischemic stroke;
- •History of the neurodegenerative diseases;
- •History of the mental disorders;
- •Use of neuroleptics, antidepressants for the last 5 years;
- •History of the cardiac surgery in the past;
- •Patients with chronic pulmonary disease (GOLD 3-4)
Arms & Interventions
propofol
Patient sedation after cardiac surgery at the intensive care unit. Continuous infusion of propofol (hypnotic agent) using a syringe pump at the dose of 1-1.5 mg / kg / h
Intervention: Propofol
Dexmedetomidine
Patient sedation after cardiac surgery at the intensive care unit. continuous infusion of Dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist) using a syringe pump at the dose of 0.5-1.0 mcg/ kg / h
Intervention: Dexmedetomidine
propofol and dexmedetomidine
Patient sedation after cardiac surgery at the intensive care unit. Continuous infusion of propofol using a syringe pump at the dose of 0.5-1.5 mg / kg / h and dexmedetomidine 0.2-0.7 mcg\\kg\\h
Intervention: Propofol and dexmedetomidine
Outcomes
Primary Outcomes
length of the mechanical ventilation
Time Frame: after cardiac surgery till extubation (up to first 24 hour after surgery)
measure the length of the mechanical ventilation
Secondary Outcomes
- Length of the ICU stay(at the day of discharge of ICU (assessed up to day 5))
- Length of the hospital stay(at the day of discharge of hospital (assessed up to day 5))