NCT02366299WithdrawnPhase 4
Comparison of Sedative Effects of Dexmedetomidine and Propofol on the Clinical Course of Delirium and Neuroinflammation in Patients With SIRS.
Moscow Regional Research and Clinical Institute (MONIKI)0 sitesStarted: February 2015Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Status
- Withdrawn
- Sponsor
- Primary Endpoint
- CAM-ICU scale
Study Overview
Brief Summary
Assessment of sedative effects of dexmedetomidine and propofol on the clinical course of delirium and neuroinflammation in patients with SIRS using CAM-ICU scale and protein S100b in serum.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •presence of delirium
Exclusion Criteria
- •presence of Alzheimer's disease
- •any mental disorder
- •presence of cancer
Arms & Interventions
dexmedetomidine
Active Comparator
Treatment of delirium by dexmedetomidine i.v. infusion
Intervention: Dexmedetomidine (Drug)
propofol
Active Comparator
Treatment of delirium by propofol i.v. infusion
Intervention: Propofol (Drug)
Outcomes
Primary Outcomes
CAM-ICU scale
Time Frame: up to 5 days
Secondary Outcomes
No secondary outcomes reported
Investigators
Valery V. Likhvantsev, Professor
senior researcher
Moscow Regional Research and Clinical Institute (MONIKI)
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