Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects
Phase 4
Completed
- Conditions
- Healthy
- Registration Number
- NCT00344955
- Lead Sponsor
- Regional Hospital Holstebro
- Brief Summary
We wanted to test the acute effect of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Both men and women
- Age: Between 20-50
- BMI<30
Exclusion Criteria
- Clinical signs or history of disease of heart, lungs, kidneys or endocrine organs.
- Abnormal lab. tests( haemoglobin, pl. sodium, pl. potassium, pl.creatinine, pl.bilirubin, pl.ALAT, pl. cholesterol, blood glucose)
- Albuminuria or glucosuria
- Cancer
- Art. hypertension
- Alcohol abuse
- Medical treatment, except oral contraceptives
- Pregnancy or breast feeding
- Blood donation less than 1 month before study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method GFR RPF FEna FELi CLna CLli
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical Research
🇩🇰Holstebro, Denmark