Metabolic Responses of Diet-Exercise Combinations in Women With Obesity: A Comparative Lifestyle Intervention Study With Different Diet Types
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Change in Body Weight
研究概览
简要总结
This study investigates the effects of different dietary strategies (ketogenic diet, intermittent fasting, and semi-vegetarian diet), alone or in combination with a structured home-based exercise program, on anthropometric, metabolic, and hormonal parameters in women with obesity. A total of 108 participants aged 19-45 years are allocated into nine groups, including control, exercise-only, diet-only, and combined intervention groups. Anthropometric outcomes (body weight, body mass index, and body fat percentage) and biochemical markers (glucose, insulin, adiponectin, IGF-1, irisin, and myostatin) are assessed at baseline and after a 6-week intervention period using bioelectrical impedance analysis and ELISA methods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Medically and physically fit for exercise interventions.
- •No participation in any structured dietary programs within the previous 3 months.
- •Lack of orthopedic limitations that would prevent safe physical activity.
排除标准
- •Pregnancy or lactation.
- •Chronic conditions such as cancer, renal failure, or hepatic failure.
- •Diagnosed psychiatric disorders.
- •History of adverse reactions to venipuncture.
- •Inability or unwillingness to adhere to the assigned dietary and exercise intervention protocols.
结局指标
主要结局
Change in Body Weight
时间窗: Baseline and 6 weeks
Body weight will be measured in kilograms (kg) using a calibrated Bioelectrical Impedance Analysis (BIA) device (Omron Karadascan HBF-511, Japan). The outcome will evaluate the effectiveness of the 6-week lifestyle interventions on body mass reduction compared to baseline.
次要结局
- Change in Fasting Blood Glucose(Baseline and week 6)
- Change in Body Mass Index (BMI)(Baseline and week 6)
- Change in Body Fat Percentage(Baseline and week 6)
- Change in Fasting Insulin(Baseline and week 6)
- Change in Skeletal Muscle Percentage(Baseline and week 6)
- Change in Adiponectin Levels(Baseline and week 6)
- Change in Insulin-Like Growth Factor 1 (IGF-1) Levels(Baseline and week 6)
- Change in Irisin Levels(Baseline and week 6)
- Change in Myostatin Levels(Baseline and week 6)
研究者
Elif Subaşı
PhD Student
Firat University