Enhancing Prospective Thinking in Early Recovery (NERF)

Not Applicable

Recruiting

• Conditions: Alcohol Use Disorder
• Interventions: Behavioral: High-Intensity Cue; Behavioral: Low-Intensity Cue

• Registration Number: NCT06283446
• Lead Sponsor: Indiana University

Brief Summary

The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question\[s\] this trial aims to answer are:

Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues? Will high-intensity EFT cues effect greater treatment-seeking interest? Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity) Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS? Will the novel behavioral SS decision-making task activate the nucleus accumbens? Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-20
• Study First Submitted: 2024-02-21
• Study First Submitted QC: 2024-02-21
• Study First Posted: 2024-02-28
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-19
• Last Update Posted: 2025-03-24
• Primary Completion: 2025-07-31
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Abstinence between 30 days ≤ 1 year
• Verbal endorsement of commitment to recovery
• English comprehension

Exclusion Criteria

• Unstable medical disorders
• Outside the age range of 18-60
• Habitual substance or alcohol use
• Smell/taste disorders
• Unstable psychiatric conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-Intensity	High-Intensity Cue	Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task.
Low-Intensity (Control)	Low-Intensity Cue	Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task.

Primary Outcome Measures

Name	Time	Method
Increase Prospective Thinking	[Time Frame: Study Day Visit (Day 1)]	High-intensity episodic future-thinking image cues will increase prospective thinking.
Delayed Rewards	[Time Frame: Study Day Visit (Day 1)]	High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.

Trial Locations

Locations (1)

Indiana University School of Medicine - Goodman Hall; 🇺🇸 Indianapolis, Indiana, United States