Enhancing Prospective Thinking in Early Recovery (BEAM)

Not Applicable

Completed

• Conditions: Alcohol Use Disorder
• Interventions: Behavioral: High-Intensity Cue; Behavioral: Low-Intensity Cue

• Registration Number: NCT06283472
• Lead Sponsor: Indiana University

Brief Summary

The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question\[s\] this trial aims to answer are:

* Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?

* Will high-intensity EFT cues effect greater treatment-seeking interest?

* Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)

* Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?

* Will the novel behavioral SS decision-making task activate the nucleus accumbens?

Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-02-21
• Study First Submitted QC: 2024-02-21
• Study First Posted: 2024-02-28
• Study Start: 2024-06-17
• Primary Completion: 2024-11-30
• Study Completion: 2024-11-30
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-10
• Last Update Posted: 2024-12-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores ≥8)
• English comprehension

Exclusion Criteria

• Unstable medical disorders
• Outside the age range of 18-60
• Smell/taste disorders
• Unstable psychiatric conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-Intensity	High-Intensity Cue	Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task.
Low-Intensity (Control)	Low-Intensity Cue	Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task.

Primary Outcome Measures

Name	Time	Method
Increase Prospective Thinking	Study Day Visit (Day 1)	High-intensity episodic future-thinking image cues will change prospective thinking.
Delayed Rewards	Study Day Visit (Day 1)	High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.

Trial Locations

Locations (1)

Indiana University School of Medicine - Goodman Hall; 🇺🇸 Indianapolis, Indiana, United States