Comparison of clinical parameters and cytokines according to the fermentation of Kimchi in patients with metabolic syndrome

Not Applicable

Completed

Conditions: Endocrine, nutritional and metabolic disease

Registration Number: KCT0000620

Lead Sponsor: Ajou University Hospital

Brief Summary: (1) Effect of consumption of Kimchi : Increased intake of dietary fiber : Decreased body weight, BMI, and waist circumference : Decreased fasting insulin, HOMA-IR, a parameter of insulin resistance : Increased Matsuda index, a parameter of insulin secretion (2) Effect of consumption of fermented Kimchi : Increased QUICKI index, a parameter of insulin sensitivity (3) The percentage of subjects who showed improved glucose tolerance : fresh Kimchi- 9.5%, fermented Kimchi- 33.3%

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 30

Inclusion Criteria

? waist circumference (WC) > 90 cm in men or > 80 cm in women
? triglycerides (TG) = 150 mg/dL
? high density lipoprotein-cholesterol < 40 mg/dL in men or < 50 mg/dL in women
? blood pressure = 130/85 mmHg
? fasting glucose = 100 mg/dL

Subjects were enrolled if they have two or more components of the aboves.

Exclusion Criteria

(1) taking medication for thyroid disease, (2) decreased renal function
(serum creatinine >1.3 mg/dL), (3) abnormal liver function (aspartate aminotransferase, alanine aminotransferase, or total bilirubin >2 times the upper normal limit), (4) congestive heart failure (New York Heart Association Class III or IV), (5) cancer, (6) pregnancy or lactation, or (7) started a new exercise program or had significant weight changes within the past 3 months.

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anthropometric parameters: body weight, BMI, waist circumference, body fat, blood pressure

Secondary Outcome Measures

Name	Time	Method
aboratory parameters: glucose/C-peptide/Insulin using oral glucose tolerance test, lipid profile, markers associated with insulin resistance and sensitivity, cytokines