Differences in antihypertensive drug levels in patients with hypertension: old vs young - 2
Recruiting
- Conditions
- 10057166High blood pressure
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
- Use of oral perindopril 2, 4 or 8 mg a day or losartan 25, 50 or 100 mg a day
or in case of healthy controls willingness to use perindopril 4 mg or losartan
50 mg for five days
- Age between 18-50 years or > 70 years
- Providing informed consent after reading the patient information
- Stopping is in accordance with the treating physician
Exclusion Criteria
• Not providing informed consent or not capable of giving informed consent, •
End-stage renal disease (eGFR<15 ml/min) • Use of other antihypertensive drugs
prescribed that are of influence on the RAAS system incuding diuretics, beta
blockers and other RAAS-inhibitors.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our primary objective is to determine if there is a difference in exposure to<br /><br>losartan and perindopril measured with the (AUC) when comparing elderly (>70<br /><br>years) with younger patients (<50 years).</p><br>
- Secondary Outcome Measures
Name Time Method <p>We want to determine if there is a difference in the drop of blood pressure<br /><br>between older (>70 years) and younger (<50 years) patients; and if so, can this<br /><br>difference be explained by a difference in the plasma concentration of the<br /><br>drug. Furthermore, we want to investigate wat the influence is of the AUC on<br /><br>RAAS-activity during the use of perindopril or losartan. Lastly, we want to<br /><br>investigate if more parameters, besides age, are of influence on the AUC that<br /><br>can explain the possible difference.</p><br>