CTRI/2024/03/063453尚未招募2 期
Comparison of the effect of intraoperative intravenous lidocaine and dexmedetomidine infusions on post-operative pain and recovery profile in spine surgeries – A Randomized non-inferiority trial.
Jawaharlal institute of Postgraduate Medical Education and Research1 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2025年8月1日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Comparison of 24 hours post-operative morphine consumption between the groups using patient-controlled analgesia
研究概览
简要总结
Comparison of the effect of intraoperativeintravenous lidocaine and dexmedetomidine infusions on post-operative pain andrecovery profile in spine surgeries – A Randomized non-inferiority trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •a.Inclusion criteria: Patients scheduled for elective spine surgeries (one or two vertebrae levels) under General anesthesia 1.Adult patients aged 18-70years belonging to either sex.
- •2.American society of Anesthesiologists (ASA) physical status 1-2.
排除标准
- •b.Exclusion criteria: 1.Allergy to any of the drugs used in the study i.e., lidocaine and dexmedetomidine.
- •2.Patients having impaired hepatic or renal function or ischemic heart disease.
- •3.Patients with conduction blocks or arrhythmias.
- •4.Patients with psychiatric illness and seizure disorder.
- •5.Patients who are on opioid supplements for pain management within two weeks of surgery.
结局指标
主要结局
Comparison of 24 hours post-operative morphine consumption between the groups using patient-controlled analgesia
时间窗: Postoperatively all patients will have access to PCA pump for 24 hours to receive a bolus of 1 mg morphine with a lock-out interval of 15 minutes without background infusion.
次要结局
- Comparison of(1 Intraoperative fentanyl requirement between the groups)
研究者
研究点 (1)
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