Comparison of the effect of intraoperative intravenous lidocaine and dexmedetomidine infusions on post-operative pain and recovery profile in spine surgeries

Phase 2

Not yet recruiting

• Conditions: Disease of spinal cord, unspecified,

• Registration Number: CTRI/2024/03/063453
• Lead Sponsor: Jawaharlal institute of Postgraduate Medical Education and Research

Brief Summary

Comparison of the effect of intraoperativeintravenous lidocaine and dexmedetomidine infusions on post-operative pain andrecovery profile in spine surgeries – A Randomized  non-inferiority trial.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-01-26
• Study Start: 2025-08-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• a.Inclusion criteria: Patients scheduled for elective spine surgeries (one or two vertebrae levels) under General anesthesia 1.Adult patients aged 18-70years belonging to either sex.
• 2.American society of Anesthesiologists (ASA) physical status 1-2.

Exclusion Criteria

• b.Exclusion criteria: 1.Allergy to any of the drugs used in the study i.e., lidocaine and dexmedetomidine.
• 2.Patients having impaired hepatic or renal function or ischemic heart disease.
• 3.Patients with conduction blocks or arrhythmias.
• 4.Patients with psychiatric illness and seizure disorder.
• 5.Patients who are on opioid supplements for pain management within two weeks of surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of 24 hours post-operative morphine consumption between the groups using patient-controlled analgesia	Postoperatively all patients will have access to PCA pump for 24 hours to receive a bolus of 1 mg morphine with a lock-out interval of 15 minutes without background infusion.

Secondary Outcome Measures

Name	Time	Method
Comparison of	1 Intraoperative fentanyl requirement between the groups

Trial Locations

Locations (1)

Jawaharlal Institute of Post-Graduate Medical Education and Research; 🇮🇳 Pondicherry, PONDICHERRY, India

Jawaharlal Institute of Post-Graduate Medical Education and Research

🇮🇳Pondicherry, PONDICHERRY, India

Dr MOHAMMED

Principal investigator

8252341058

mohammedjolam@gmail.com