Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

Completed

• Conditions: Appendiceal Cancer
• Interventions: Procedure: Partial colecctomy; Procedure: Hemicolectomy

• Registration Number: NCT05452382
• Lead Sponsor: Mansoura University

Brief Summary

A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2005-01-01
• Primary Completion: 2019-12-30
• Status Verified: 2022-07
• Study Completion: 2022-07-06
• Study First Submitted: 2022-07-06
• Study First Submitted QC: 2022-07-06
• Last Update Submitted: 2022-07-06
• Study First Posted: 2022-07-11
• Last Update Posted: 2022-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2607

Inclusion Criteria

• patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection

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Exclusion Criteria

• Patients with other pathologic types of appendiceal cancer
• Patients with clinical stage IV or unknown stage
• Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Partial colectomy	Partial colecctomy	Patients with appendiceal cancer who underwent segmental resection of appendiceal adenocarcinoma
Hemicolectomy	Hemicolectomy	Patients with appendiceal cancer who underwent formal right hemicolectomy of appendiceal adenocarcinoma

Primary Outcome Measures

Name	Time	Method
Overall survival	60 months	Percent of patients who were alive at five years of follow-up

Secondary Outcome Measures

Name	Time	Method
Positive resection margins	Immediate postoperative	the rate of surgical margins infiltrated by malignancy

Trial Locations

Locations (1)

Cleveland Clinic Flroida; 🇺🇸 Weston, Florida, United States