Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma; a National Cancer Database Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,607
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection
排除标准
- •Patients with other pathologic types of appendiceal cancer
- •Patients with clinical stage IV or unknown stage
- •Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery
结局指标
主要结局
Overall survival
时间窗: 60 months
Percent of patients who were alive at five years of follow-up
次要结局
- Positive resection margins(Immediate postoperative)
研究者
Sameh Emile
Research associate
Cleveland Clinic Florida