A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema
- Registration Number
- NCT04432831
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This is a multicenter long-term extension study designed to evaluate the long-term safety and tolerability of faricimab administered by intravitreal (IVT) injection at a personalized treatment interval (PTI) to participants who enrolled in and completed one of the two Phase III studies, GR40349 (NCT03622580) or GR40398 (NCT03622593), also referred to as the parent studies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1479
- Previous enrollment in and completion of Study GR40349 (NCT03622580) or GR40398 (NCT03622593), without study or study drug discontinuation
- Ability to comply with the study protocol, in the investigator's judgment
- For women of childbearing potential: agreement to remain abstinent or use acceptable contraceptive methods that result in a failure rate of <1% per year during the treatment period and for at least 3 months after the final dose of study treatment
- Pregnant or breastfeeding, or intending to become pregnant during the study or within 3 months after the final intravitreal injection of faricimab
- Presence of other ocular diseases that give reasonable suspicion of a disease or condition that contraindicates the use of faricimab, that might affect interpretation of the results of the study or that renders the patient at high risk for treatment complications
- Presence of other diseases, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of faricimab and that might affect interpretation of the results of the study or that renders the patient at high risk of treatment complications
- History of a severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the faricimab injections, study treatment procedure, dilating drops, or any of the anesthetic and antimicrobial preparations used by a patient during the study
- Requirement for continuous use of any medications or treatments indicated as prohibited therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Faricimab PTI Sham Procedure - Faricimab PTI Faricimab -
- Primary Outcome Measures
Name Time Method Incidence and Severity of Ocular Adverse Events in the Study Eye, With Severity Determined According to Adverse Event Severity Grading Scale From the day of the first dose of faricimab until the end of the study (up to 108 weeks) This is an analysis of participants with at least one ocular adverse event (AE) that occurred in the study eye. Investigators sought information on AEs at each contact with the participants. All AEs were recorded and the investigator made an assessment of the seriousness, severity (e.g., mild, moderate, or severe intensity), and causality for each AE. AEs of special interest (AESI) included the following: Sight-threatening AEs that cause a drop in visual acuity (VA) score ≥30 letters lasting more than 1 hour, are associated with severe intraocular inflammation (IOI), or require surgical or medical intervention to prevent permanent loss of sight; suspected transmission of an infectious agent by the study drug; and, cases of potential drug-induced liver injury that include an elevated ALT or AST in combination with either an elevated bilirubin or clinical jaundice, as defined by Hy's Law.
Incidence of Ocular Adverse Events in the Fellow Eye From the day of the first dose of faricimab until the end of the study (up to 108 weeks) This is an analysis of participants with at least one ocular adverse event (AE) that occurred in the fellow eye (i.e., non-study eye). Investigators sought information on AEs at each contact with the participants. All AEs were recorded and the investigator made an assessment of the seriousness, severity, and causality for each AE. AEs of special interest (AESI) included the following: Sight-threatening AEs that cause a drop in visual acuity (VA) score ≥30 letters lasting more than 1 hour, are associated with severe intraocular inflammation (IOI), or require surgical or medical intervention to prevent permanent loss of sight; suspected transmission of an infectious agent by the study drug; and, cases of potential drug-induced liver injury that include an elevated ALT or AST in combination with either an elevated bilirubin or clinical jaundice, as defined by Hy's Law.
Incidence and Severity of Non-Ocular Adverse Events, With Severity Determined According to Adverse Event Severity Grading Scale From the day of the first dose of faricimab until the end of the study (up to 108 weeks) This is an analysis of participants with at least one non-ocular (systemic) adverse event (AE). Investigators sought information on AEs at each contact with the participants. All AEs were recorded and the investigator made an assessment of the seriousness, severity (e.g., mild, moderate, or severe intensity), and causality for each AE. AEs of special interest (AESI) included the following: Sight-threatening AEs that cause a drop in visual acuity (VA) score ≥30 letters lasting more than 1 hour, are associated with severe intraocular inflammation (IOI), or require surgical or medical intervention to prevent permanent loss of sight; suspected transmission of an infectious agent by the study drug; and, cases of potential drug-induced liver injury that include an elevated ALT or AST in combination with either an elevated bilirubin or clinical jaundice, as defined by Hy's Law.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (318)
Barnet Dulaney Perkins Eye Center
🇺🇸Mesa, Arizona, United States
Retinal Research Institute, LLC
🇺🇸Phoenix, Arizona, United States
Arizona Retina and Vitreous Consultants
🇺🇸Phoenix, Arizona, United States
Retina Associates Southwest PC
🇺🇸Tucson, Arizona, United States
California Retina Consultants.
🇺🇸Bakersfield, California, United States
Retina-Vitreous Associates Medical Group
🇺🇸Beverly Hills, California, United States
Retinal Diagnostic Center
🇺🇸Campbell, California, United States
The Retina Partners
🇺🇸Encino, California, United States
Eye Medical Center
🇺🇸Fresno, California, United States
Retina Consultants of Orange County
🇺🇸Fullerton, California, United States
Southern California Permanente Medical Group
🇺🇸Los Angeles, California, United States
Northern California Retina Vitreous Associates
🇺🇸Mountain View, California, United States
East Bay Retina Consultants
🇺🇸Oakland, California, United States
Southern CA Desert Retina Cons
🇺🇸Palm Desert, California, United States
California Eye Specialists Medical group Inc.
🇺🇸Pasadena, California, United States
Retina Consultants, San Diego
🇺🇸Poway, California, United States
Retina Consultants of Southern California
🇺🇸Redlands, California, United States
Retinal Consultants Med Group
🇺🇸Sacramento, California, United States
West Coast Retina Medical Group
🇺🇸San Francisco, California, United States
Orange County Retina Med Group
🇺🇸Santa Ana, California, United States
California Retina Consultants
🇺🇸Santa Barbara, California, United States
California Retina Consultants - Santa Maria
🇺🇸Santa Maria, California, United States
Bay Area Retina Associates
🇺🇸Walnut Creek, California, United States
University of Colorado; dept of ophthalmology
🇺🇸Aurora, Colorado, United States
Retina Consultants of Southern
🇺🇸Colorado Springs, Colorado, United States
Colorado Retina Associates, PC
🇺🇸Lakewood, Colorado, United States
Retina Group of New England
🇺🇸Waterford, Connecticut, United States
Rand Eye
🇺🇸Deerfield Beach, Florida, United States
Retina Group of Florida
🇺🇸Fort Lauderdale, Florida, United States
National Ophthalmic Research Institute
🇺🇸Fort Myers, Florida, United States
Florida Eye Associates
🇺🇸Melbourne, Florida, United States
Retina Care Specialists
🇺🇸Palm Beach Gardens, Florida, United States
Retina Specialty Institute
🇺🇸Pensacola, Florida, United States
Fort Lauderdale Eye Institute
🇺🇸Plantation, Florida, United States
Retina Vitreous Assoc of FL
🇺🇸Saint Petersburg, Florida, United States
Southern Vitreoretinal Assoc
🇺🇸Tallahassee, Florida, United States
Retina Associates of Florida, LLC
🇺🇸Tampa, Florida, United States
Southeast Retina Center
🇺🇸Augusta, Georgia, United States
Georgia Retina PC
🇺🇸Marietta, Georgia, United States
Retina Consultants of Hawaii
🇺🇸'Aiea, Hawaii, United States
University Retina and Macula Associates, PC
🇺🇸Oak Forest, Illinois, United States
Prairie Eye & LASIK Center / Prairie Retina Center
🇺🇸Springfield, Illinois, United States
Midwest Eye Institute
🇺🇸Indianapolis, Indiana, United States
Wolfe Eye Clinic
🇺🇸West Des Moines, Iowa, United States
Retina Associates
🇺🇸Lenexa, Kansas, United States
Vitreo-Retinal Consultants
🇺🇸Wichita, Kansas, United States
Retina Associates of Kentucky
🇺🇸Lexington, Kentucky, United States
Maine Eye Center
🇺🇸Portland, Maine, United States
The Retina Care Center
🇺🇸Baltimore, Maryland, United States
Johns Hopkins Med; Wilmer Eye Inst
🇺🇸Baltimore, Maryland, United States
Retina Group of Washington
🇺🇸Chevy Chase, Maryland, United States
Cumberland Valley Retina PC
🇺🇸Hagerstown, Maryland, United States
Retina Specialists
🇺🇸Towson, Maryland, United States
Tufts Medical Center; Ophthalmology
🇺🇸Boston, Massachusetts, United States
Ophthalmic Consultants of Boston
🇺🇸Boston, Massachusetts, United States
Beetham Eye Institute, Joslin Diabetes Center
🇺🇸Boston, Massachusetts, United States
Vitreo-Retinal Associates, PC
🇺🇸Worcester, Massachusetts, United States
Associated Retinal Consultants
🇺🇸Grand Rapids, Michigan, United States
Foundation for Vision Research
🇺🇸Grand Rapids, Michigan, United States
Vitreo-Retinal Associates
🇺🇸Grand Rapids, Michigan, United States
Assoc Retinal Consultants PC
🇺🇸Royal Oak, Michigan, United States
Associated Retinal Consultants, P.C.
🇺🇸Traverse City, Michigan, United States
VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota
🇺🇸Edina, Minnesota, United States
Midwest Vision Research Foundation
🇺🇸Chesterfield, Missouri, United States
Sierra Eye Associates
🇺🇸Reno, Nevada, United States
NJRetina
🇺🇸Edison, New Jersey, United States
Retinal & Ophthalmic Cons PC
🇺🇸Northfield, New Jersey, United States
Retina Associates of NJ
🇺🇸Teaneck, New Jersey, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Capital Region Retina
🇺🇸Albany, New York, United States
Long Is. Vitreoretinal Consult
🇺🇸Hauppauge, New York, United States
Retina Vit Surgeons/Central NY
🇺🇸Liverpool, New York, United States
New York University
🇺🇸New York, New York, United States
Ophthalmic Cons of Long Island
🇺🇸Oceanside, New York, United States
Retina Associates of Western New York
🇺🇸Rochester, New York, United States
Island Retina
🇺🇸Shirley, New York, United States
The Retina Consultants
🇺🇸Slingerlands, New York, United States
Western Carolina Retinal Associate PA
🇺🇸Asheville, North Carolina, United States
Char Eye Ear &Throat Assoc
🇺🇸Charlotte, North Carolina, United States
Graystone Eye
🇺🇸Hickory, North Carolina, United States
Wake Forest Baptist Health Eye Centre
🇺🇸Winston-Salem, North Carolina, United States
Cincinnati Eye Institute
🇺🇸Cincinnati, Ohio, United States
Retina Assoc of Cleveland Inc
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Foundation; Cole Eye Institute
🇺🇸Cleveland, Ohio, United States
The Ohio State University Havener Eye Institute
🇺🇸Columbus, Ohio, United States
Midwest Retina
🇺🇸Dublin, Ohio, United States
Retina Vitreous Center
🇺🇸Edmond, Oklahoma, United States
Retina Northwest
🇺🇸Portland, Oregon, United States
Mid Atlantic Retina - Wills Eye Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Mid-Atlantic Retina
🇺🇸Philadelphia, Pennsylvania, United States
Retina Consultants Of Carolina
🇺🇸Greenville, South Carolina, United States
Charleston Neuroscience Inst
🇺🇸Ladson, South Carolina, United States
Palmetto Retina Center
🇺🇸West Columbia, South Carolina, United States
Southeastern Retina Associates Chattanooga
🇺🇸Chattanooga, Tennessee, United States
Charles Retina Institute
🇺🇸Germantown, Tennessee, United States
Tennessee Retina PC
🇺🇸Nashville, Tennessee, United States
Retina Res Institute of Texas
🇺🇸Abilene, Texas, United States
Austin Retina Associates
🇺🇸Austin, Texas, United States
Austin Clinical Research LLC
🇺🇸Austin, Texas, United States
Retina & Vitreous of Texas
🇺🇸Bellaire, Texas, United States
Texas Retina Associates
🇺🇸Dallas, Texas, United States
Valley Retina Institute P.A.
🇺🇸Harlingen, Texas, United States
Medical Center Ophthalmology Associates
🇺🇸San Antonio, Texas, United States
Retina Center of Texas
🇺🇸Southlake, Texas, United States
Retina Consultants of Texas
🇺🇸The Woodlands, Texas, United States
Eye Care Assoc of East Texas
🇺🇸Tyler, Texas, United States
Strategic Clinical Research Group, LLC
🇺🇸Willow Park, Texas, United States
Retina Associates of Utah, PLLC
🇺🇸Salt Lake City, Utah, United States
University of Utah; Division of Gastroenterology/Hepatology
🇺🇸Salt Lake City, Utah, United States
Uni of Vermont Medical Center;
🇺🇸Burlington, Vermont, United States
Univ of Virginia Ophthalmology
🇺🇸Charlottesville, Virginia, United States
Emerson Clinical Research Institute
🇺🇸Falls Church, Virginia, United States
Piedmont Eye Center
🇺🇸Lynchburg, Virginia, United States
Wagner Kapoor Institute
🇺🇸Norfolk, Virginia, United States
Retina Institute of Virginia
🇺🇸Richmond, Virginia, United States
West Virginia University Eye Institute
🇺🇸Morgantown, West Virginia, United States
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
Fundacion Zambrano
🇦🇷Caba, Argentina
Oftalmos
🇦🇷Capital Federal, Argentina
Oftar
🇦🇷Mendoza, Argentina
Centro Oftalmólogos Especialistas
🇦🇷Rosario, Argentina
Grupo Laser Vision
🇦🇷Rosario, Argentina
Organizacion Medica de Investigacion
🇦🇷San Nicolás, Argentina
Strathfield Retina Clinic
🇦🇺Strathfield, New South Wales, Australia
Sydney Eye Hospital
🇦🇺Sydney, New South Wales, Australia
Sydney Retina Clinic and Day Surgery
🇦🇺Sydney, New South Wales, Australia
Sydney West Retina
🇦🇺Westmead, New South Wales, Australia
Centre For Eye Research Australia
🇦🇺East Melbourne, Victoria, Australia
Retina Specialists Victoria
🇦🇺Rowville, Victoria, Australia
The Lions Eye Institute
🇦🇺Nedlands, Western Australia, Australia
LKH-Univ.Klinikum Graz; Universitäts-Augenklinik
🇦🇹Graz, Austria
Kepler Universitätskliniken GmbH - Med Campus III; Abt. für Augenheilkunde
🇦🇹Linz, Austria
Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie
🇦🇹Wien, Austria
Hanusch Krankenhaus; Abteilung für Augenkrankheiten mit Augen-Tagesklinik
🇦🇹Wien, Austria
Hospital de Olhos de Aparecida - HOA
🇧🇷Aparecida de Goiania, GO, Brazil
Centro Brasileiro de Cirurgia
🇧🇷Goiania, GO, Brazil
Hospital das Clinicas - UFRGS
🇧🇷Porto Alegre, RS, Brazil
Botelho Hospital da Visao
🇧🇷Blumenau, SC, Brazil
Faculdade de Medicina do ABC - FMABC
🇧🇷Santo Andre, SP, Brazil
Universidade Federal de Sao Paulo - UNIFESP*X; Oftalmologia
🇧🇷Sao Paulo, SP, Brazil
CEMAPE - Centro Médico
🇧🇷Sao Paulo, SP, Brazil
Hospital das Clinicas - FMUSP
🇧🇷Sao Paulo, SP, Brazil
Hosp de Olhos de Sorocaba
🇧🇷Sorocaba, SP, Brazil
Medical Center for Eye Health ? Focus Ltd
🇧🇬Sofia, Bulgaria
Pentagram Eye Hospital (Medical Center "Pentagram")
🇧🇬Sofia, Bulgaria
Spec. Ophth. Hospital for Active Treatment- Academic Pashev
🇧🇬Sofia, Bulgaria
Specialized Hospital for Active Treatment of Eye Diseases Zora
🇧🇬Sofia, Bulgaria
Calgary Retina Consultants
🇨🇦Calgary, Alberta, Canada
QEII - HSC Department of Ophthalmology
🇨🇦Halifax, Nova Scotia, Canada
Ivey Eye Institute
🇨🇦London, Ontario, Canada
Toronto Retina Institute
🇨🇦Toronto, Ontario, Canada
St. Michael's Hospital; Department of Ophthalmology
🇨🇦Toronto, Ontario, Canada
University Health Network Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Institut De L'Oeil Des Laurentides
🇨🇦Boisbriand, Quebec, Canada
FN Hradec Králové, O?ní klinika; Ophthalmology clinic
🇨🇿Hradec Králové, Czechia
Faculty Hospital Ostrava; Ophthalmology clinic
🇨🇿Ostrava, Czechia
Faculty Hospital Kralovske Vinohrady; Ophthalmology clinic
🇨🇿Prague, Czechia
AXON Clinical
🇨🇿Prague, Czechia
Nemocnice Sokolov
🇨🇿Sokolov, Czechia
Aalborg Universitetshospital; Øjenafdelingen
🇩🇰Aalborg, Denmark
Sjællands Universitetshospital, Roskilde; Øjenafdelingen
🇩🇰Roskilde, Denmark
Centre Hospitalier Universitaire de Bordeaux Hopital Pellegrin
🇫🇷Bordeaux, France
Chi De Creteil; Ophtalmologie
🇫🇷Creteil, France
Pole Vision Val d'Ouest; Ophtalmologie
🇫🇷Ecully, France
CHU Nantes - Hôtel Dieu; Ophthalmology
🇫🇷Nantes, France
Hopital Lariboisiere; Ophtalmologie
🇫🇷Paris, France
Centres Ophtalmologique St Exupéry; Ophtalmologie
🇫🇷St Cyr Sur Loire, France
Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Augenheilkunde
🇩🇪Dresden, Germany
Universitätsklinikum Freiburg, Klinik für Augenheilkunde
🇩🇪Freiburg, Germany
Medizinische Hochschule Hannover, Klinik für Augenheilkunde
🇩🇪Hannover, Germany
Universitätsklinikum des Saarlandes; Klinik für Augenheilkunde
🇩🇪Homburg/Saar, Germany
Universitätsklinikum Magdeburg A.ö.R., Universitätsaugenklinik
🇩🇪Magdeburg, Germany
LMU Klinikum der Universität, Augenklinik
🇩🇪München, Germany
Klinikum rechts der Isar der TU München; Augenklinik
🇩🇪München, Germany
Augenabteilung am St. Franziskus-Hospital
🇩🇪Münster, Germany
Universitätsklinikum Münster; Augenheilkunde
🇩🇪Münster, Germany
Universitätsklinikum Würzburg, Augenklinik und Poliklinik
🇩🇪Würzburg, Germany
Queen Mary Hospital; Department of Ophthalmology
🇭🇰Hong Kong, Hong Kong
Hong Kong Eye Hospital; CUHK Eye Centre
🇭🇰Mongkok, Hong Kong
Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Szemeszet
🇭🇺Budapest, Hungary
Peterfy Sandor utcai Korhaz-Rendelointezet es Baleseti Kozpont, Szemeszet KR
🇭🇺Budapest, Hungary
Semmelweis Egyetem Szemészeti Vizsgálóhely
🇭🇺Budapest, Hungary
Bajcsy-Zsilinszky Hospital
🇭🇺Budapest, Hungary
Budapest Retina Associates Kft.
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont; Szemeszeti Klinika
🇭🇺Debrecen, Hungary
Ganglion Medial Center
🇭🇺Pécs, Hungary
Szegedi Tudományegyetem ÁOK; Department of Ophtalmology
🇭🇺Szeged, Hungary
Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET; Intezeti Gyogyszertar
🇭🇺Szombathely, Hungary
Zala Megyei Kórház; SZEMESZET
🇭🇺Zalaegerszeg, Hungary
Rambam Medical Center; Opthalmology
🇮🇱Haifa, Israel
Hadassah MC; Ophtalmology
🇮🇱Jerusalem, Israel
Rabin MC; Ophtalmology
🇮🇱Petach Tikva, Israel
Kaplan Medical Center; Ophtalmology
🇮🇱Rehovot, Israel
Tel Aviv Sourasky MC; Ophtalmology
🇮🇱Tel Aviv, Israel
Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico
🇮🇹Roma, Lazio, Italy
UNIVERSITA' DEGLI STUDI DI GENOVA - Di.N.O.G.;CLINICA OCULISTICA
🇮🇹Genova, Liguria, Italy
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena;U.O.C Oculistica
🇮🇹Milano, Lombardia, Italy
Irccs Ospedale San Raffaele;U.O. Oculistica
🇮🇹Milano, Lombardia, Italy
Azienda Ospedaliero-Universitaria Careggi; S.O.D. Oculistica
🇮🇹Firenze, Toscana, Italy
Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria
🇮🇹Pisa, Toscana, Italy
Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia; Clinica Oculistica
🇮🇹Perugia, Umbria, Italy
Ospedale Classificato Equiparato Sacro Cuore ? Don Calabria; Presso Ufficio Cassa
🇮🇹Negrar Di Valpolicella (VR), Veneto, Italy
Sugita Eye Hospital
🇯🇵Aichi, Japan
Nagoya University Hospital
🇯🇵Aichi, Japan
Nagoya City University Hospital
🇯🇵Aichi, Japan
Aichi Medical University Hospital
🇯🇵Aichi, Japan
Toho University Sakura Medical Center
🇯🇵Chiba, Japan
Hayashi Eye Hospital
🇯🇵Fukuoka, Japan
Kurume University Hospital
🇯🇵Fukuoka, Japan
Hokkaido University Hospital
🇯🇵Hokkaido, Japan
Asahikawa Medical University Hospital
🇯🇵Hokkaido, Japan
Hyogo Prefectural Amagasaki General Medical Center (Hyogo AGMC)
🇯🇵Hyogo, Japan
Kozawa eye hospital and diabetes center
🇯🇵Ibaraki, Japan
Ideta Eye Hospital
🇯🇵Kumamoto, Japan
Kyoto University Hospital
🇯🇵Kyoto, Japan
Mie University Hospital
🇯🇵Mie, Japan
University of Miyazaki Hospital
🇯🇵Miyazaki, Japan
Nara Medical University Hospital
🇯🇵Nara, Japan
Kitano Hospital
🇯🇵Osaka, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
National Defense Medical College Hospital
🇯🇵Saitama, Japan
Shiga University Of Medical Science Hospital
🇯🇵Shiga, Japan
Tokyo Women's Medical University
🇯🇵Tokyo, Japan
Kyorin University Hospital
🇯🇵Tokyo, Japan
Tokyo Medical University Hachioji Medical Center
🇯🇵Tokyo, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Centro Oftalmológico Mira, S.C
🇲🇽Del. Cuauhtemoc, Mexico CITY (federal District), Mexico
Macula Retina Consultores
🇲🇽Mexico, D.F., Mexico CITY (federal District), Mexico
Hospital de la Ceguera APEC
🇲🇽Mexico, D.F., Mexico CITY (federal District), Mexico
Instituto de la retina del Bajio
🇲🇽Querétaro, Queretaro, Mexico
Mácula D&T
🇵🇪Lima, Peru
TG Laser Oftalmica
🇵🇪Lima, Peru
Oftalmolaser
🇵🇪Lima, Peru
Szpital sw. Lukasza
🇵🇱Bielsko-Biala, Poland
Specjalistyczny O?rodek Okulistyczny Oculomedica
🇵🇱Bydgoszcz, Poland
OFTALMIKA Sp. z o.o
🇵🇱Bydgoszcz, Poland
Szpital Specjalistyczny nr 1; Oddzial Okulistyki
🇵🇱Bytom, Poland
Dobry Wzrok Sp Z O O
🇵🇱Gda?sk, Poland
Optimum Profesorskie Centrum Okulistyki
🇵🇱Gda?sk, Poland
Poradnia Okulistyczna i Salon Optyczny w Gliwicach- PRYZMAT
🇵🇱Gliwice, Poland
Gabinet Okulistyczny Prof Edward Wylegala
🇵🇱Katowice, Poland
Centrum Medyczne UNO-MED
🇵🇱Krakow, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie Oddzia? Kliniczny Okulistyki i Onkologii Okulistycznej
🇵🇱Krakow, Poland
Optomed Sp. z o.o.
🇵🇱Rybnik, Poland
Osrodek Chirurgii Oka prof. Zagorskiego Rzeszow
🇵🇱Rzeszów, Poland
Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina; Klinika Okulistyki
🇵🇱Rzeszów, Poland
Caminomed
🇵🇱Tarnowskie Góry, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
SPEKTRUM Osrodek Okulistyki Klinicznej
🇵🇱Wroclaw, Poland
Hospital de Braga; Servico de Oftalmologia
🇵🇹Braga, Portugal
AIBILI - Association for Innovation and Biomedical Research on Light
🇵🇹Coimbra, Portugal
Espaco Medico Coimbra
🇵🇹Coimbra, Portugal
Hospital de Santa Maria; Servico de Oftalmologia
🇵🇹Lisboa, Portugal
Clinic Optimed
🇷🇺UFA, Baskortostan, Russian Federation
Intersec Research and Technology Complex ?Eye Microsurgery? n.a. S.N. Fyodorov; Cheboksary Branch
🇷🇺Cheboksary, Marij EL, Russian Federation
FSBI ?Scientific Research Institute of Eye Diseases? of Russian Academy of medical Sciences
🇷🇺Moscow, Moskovskaja Oblast, Russian Federation
Medical Military Academy n.a S.M.Kirov
🇷🇺St.Petersburg, Sankt Petersburg, Russian Federation
Clinics of Eye Diseases, LLC
🇷🇺Kazan, Tatarstan, Russian Federation
?Intersec. Research and Technology Complex ?Eye Microsurgery? n a Fyodorov Irkutsk branch
🇷🇺Irkutsk, Russian Federation
?Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch
🇷🇺Novosibirsk, Russian Federation
National University Hospital; Ophthalmology Department
🇸🇬Singapore, Singapore
Singapore Eye Research Institute
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital; Ophthalmology Department
🇸🇬Singapore, Singapore
Nemocnica s poliklinikou Trebišov, a.s.
🇸🇰Trebišov, Slovakia
Fakultna nemocnica Trencin Ocna klinika
🇸🇰Trencin, Slovakia
Fakultna nemocnica s poliklinikou Zilina; Ocne oddelenie
🇸🇰Zilina, Slovakia
Instituto Oftalmologico Fernandez Vega; Servicio de oftalmologia
🇪🇸Oviedo, Asturias, Spain
Hospital Universitario de Bellvitge
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hospital General de Catalunya
🇪🇸San Cugat Del Valles, Barcelona, Spain
Instituto Oftalmologico Gomez Ulla; Servicio de Oftalmologia
🇪🇸Santiago de Compostela, LA Coruña, Spain
Hospital Universitario de Gran Canaria; Servicio de oftalmologia
🇪🇸Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital Universitario Puerta de Hierro
🇪🇸Majadahonda, Madrid, Spain
Clinica Universitaria de Navarra; Servicio de Oftalmologia
🇪🇸Pamplona, Navarra, Spain
Complejo Hospitalario de Navarra; Servicio de oftalmologia
🇪🇸Pamplona, Navarra, Spain
Oftalvist Valencia
🇪🇸Burjassot, Valencia, Spain
Complejo Hospitalario Universitario Albacete; Servicio de oftalmologia
🇪🇸Albacete, Spain
VISSUM Instituto Oftalmológico de Alicante
🇪🇸Alicante, Spain
Centro de Oftalmologia Barraquer; Servicio Oftalmologia
🇪🇸Barcelona, Spain
Hospital dos de maig; servicio de oftalmologia
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona; Consultas Externas Oftalmologia
🇪🇸Barcelona, Spain
Hospital de Santa Creu I Sant Pau; Servicio de Oftalmologia
🇪🇸Barcelona, Spain
Clinica Baviera; Servicio Oftalmologia
🇪🇸Madrid, Spain
Fisabio-Ofalmologia Medica; Servicio de Oftalmología
🇪🇸Valencia, Spain
Hospital Universitario Rio Hortega; Servicio de Oftalmologia
🇪🇸Valladolid, Spain
Vista Klinik Ophthalmologische Klinik
🇨🇭Binningen, Switzerland
Taipei Veterans General Hospital; Ophthalmology
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation - Linkou; Ophthalmology
🇨🇳Taoyuan, Taiwan
National Taiwan University Hospital; Ophthalmology
🇨🇳Zhongzheng Dist., Taiwan
King Chulalongkorn Memorial Hospital; Ophthalmology Department
🇹🇭Bangkok, Thailand
Rajavithi Hospital; Ophthalmology Department
🇹🇭Bangkok, Thailand
Maharaj Nakorn ChiangMai Hospital; Ophthalmology Department
🇹🇭ChiangMai, Thailand
Hacettepe University Medical Faculty; Department of Ophthalmology
🇹🇷Ankara, Turkey
Ankara University Medical Faculty; Department of Ophthalmology
🇹🇷Ankara, Turkey
Ankara Baskent University Medical Faculty; Department of Ophthalmology
🇹🇷Ankara, Turkey
Beyoglu Goz Training and Research Hospital; Department Of Ophthalmology
🇹🇷Istanbul, Turkey
Ege University Medical Faculty; Department of Ophthalmology
🇹🇷Izmir, Turkey
Kocaeli Üniversitesi T?p Fakültesi; Department of Ophthalmology
🇹🇷Kocaeli, Turkey
Selcuk University Faculty of Medicine; Department Of Ophthalmology
🇹🇷Konya, Turkey
Belfast Health and Social Care Trust, ROYAL VICTORIA HOSPITAL
🇬🇧Belfast, United Kingdom
Bradford Royal Infirmary
🇬🇧Bradford, United Kingdom
East Kent Hospitals University NHS Foundation Trust
🇬🇧Canterbury, United Kingdom
Frimley Park Hospital
🇬🇧Frimley, United Kingdom
Gloucestershire Hospitals NHS Foundation Trust
🇬🇧Gloucestershire, United Kingdom
St James University Hospital
🇬🇧Leeds, United Kingdom
Royal Liverpool University Hospital; St Paul's Clinical Eye Research Centre
🇬🇧Liverpool, United Kingdom
Moorfields Eye Hospital NHS Foundation Trust
🇬🇧London, United Kingdom
Royal Free Hospital
🇬🇧London, United Kingdom
Kings College Hospital
🇬🇧London, United Kingdom
Manchester Royal Eye Hospital
🇬🇧Manchester, United Kingdom
Hillingdon Hospital
🇬🇧Middx, United Kingdom
Royal Victoria Infirmary
🇬🇧Newcastle upon Tyne, United Kingdom
James Paget University Hospitals NHS Foundation Trust
🇬🇧Norfolk, United Kingdom
University Hospital Southampton NHS Foundation Trust; Southampton Eye Unit
🇬🇧Southampton, United Kingdom
Sunderland Eye Infirmary
🇬🇧Sunderland, United Kingdom