Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age

Completed

• Conditions: Arterial Stiffness

• Registration Number: NCT06151054
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Detailed Description

In the literature, a relationship has been demonstrated between local inflammation in the aortic wall and increased arterial stiffness. Arterial stiffness is commonly represented by pulse wave velocity (PWV) measured using an applanation tonometer. It would seem that this parietal inflammation precedes arterial stiffness and consequently, arterial hypertension . Arterial stiffness is an important factor of cardiovascular morbidity and mortality and therefore represents a major public health interest in prevention in the face of the continuous aging of our population . This study will consist in studying on a population divided into three age groups, less than 40 years old, 40 to 60 years old and more than 60 years old, the relationship between thoracic aortic parietal inflammation evaluated using the Standard Uptake Value parameters (SUV) and Hounsfield units (HU) measured on 18F-FDG PET/CT scans performed between 09/04/2018 and 11/06/2020 and arterial stiffness parameters. We will seek to show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Study Timeline

• Study First Submitted: 2022-09-08
• Study Start: 2022-10-30
• Primary Completion: 2022-11-30
• Study Completion: 2022-12-06
• Status Verified: 2023-11
• Study First Submitted QC: 2023-11-28
• Last Update Submitted: 2023-11-28
• Study First Posted: 2023-11-30
• Last Update Posted: 2023-11-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

• Patients who underwent whole-body 18F-FDG PET/CT included in the PACTEP study
• Patient with an assessment of arterial stiffness by applanation tonometer

Exclusion Criteria

• patients without an assessment of arterial stiffness by applanation tonometer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to etablish a relationship inflammation of aortic wall and arterial stiffness	1 day	Standard Uptake Value

Trial Locations

Locations (1)

CHRU Nancy; 🇫🇷 Vandoeuvre les Nancy cedex, France