Postoperative Pain Control for Prostatectomy

Not Applicable

Completed

• Conditions: Prostate Cancer
• Interventions: Procedure: Transverse Abdominal Plan (TAP); Procedure: standard post op pain control

• Registration Number: NCT00913068
• Lead Sponsor: Nova Scotia Health Authority

Brief Summary

The researchers propose to investigate a relatively new anesthetic procedure, in order to maximize patient comfort and minimize the use of narcotics after a radical prostatectomy.

Detailed Description

Our current post operative analgesic strategy involves a multi-modal approach, using local injectable anesthetic around the incision and systemic medications (i.e. non-steroidal anti-inflammatories, acetaminophen and break-through doses of opiates). As the amount of opiates used can be significant, we have to be aware of their inherent risks. Opiates have an excellent pain control profile, working peripherally by decreasing the amount of neurotransmitters released from neurons involving noxious stimuli, and also in their central processing. Some of the more common adverse reactions are reparatory depression, sedation, confusion, delirium, nausea, pruritis, constipation, hypotension and bradycardia. Often it is these resulting side effects that extend the length of in hospital rehabilitation, and decrease a patient's overall satisfaction.

Thus we propose the use of a relatively new regional anesthetic technique be employed to further decrease the need for opiates in our prostatectomy patients' post-op course, while adequately controlling their pain.

Study Timeline

• Study First Submitted: 2009-06-01
• Study First Submitted QC: 2009-06-02
• Study First Posted: 2009-06-03
• Study Start: 2009-07
• Primary Completion: 2011-09
• Study Completion: 2011-09
• Results First Submitted: 2021-07-27
• Status Verified: 2021-09
• Results First Submitted QC: 2021-09-03
• Last Update Submitted: 2021-09-03
• Results First Posted: 2021-10-04
• Last Update Posted: 2021-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 110

Inclusion Criteria

• prostate cancer for radical prostatectomy

Exclusion Criteria

• chronic pain or opiate use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TAP arm	Transverse Abdominal Plan (TAP)	in the experimental arm, the procedure will consist of the staff urologist injecting local anesthetic into the anterior abdominal wall bilaterally from the inside of the abdomen at the end of their surgery
standard post operative pain control	standard post op pain control	Our current post operative analgesic strategy involves a multi-modal approach, using local injectable anesthetic around the incision and systemic medications (i.e. non-steroidal anti-inflammatories, acetaminophen and break-through doses of opiates). Some of the more common adverse reactions are reparatory depression, sedation, confusion, delirium, nausea, pruritis, constipation, hypotension and bradycardia. Often it is these resulting side effects that extend the length of in hospital rehabilitation, and decrease a patient's overall satisfaction.

Primary Outcome Measures

Name	Time	Method
Total Milligrams of Opiates	2, 6,12, 24, 48 and 72 hours	mean number of milligrams used postoperatively

Trial Locations

Locations (1)

Queen Elizabeth Health Sciences Centre; 🇨🇦 Halifax, Nova Scotia, Canada