Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

Not Applicable

• Conditions: Lung Disease,Obstructive
• Interventions: Drug: No drugs; Drug: Salbutamol Aerosol

• Registration Number: NCT02592122
• Lead Sponsor: snow

Brief Summary

In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Status Verified: 2015-10
• Study First Submitted: 2015-10-11
• Study First Submitted QC: 2015-10-29
• Last Update Submitted: 2015-10-29
• Study First Posted: 2015-10-30
• Last Update Posted: 2015-10-30
• Primary Completion: 2016-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Acute exacerbation of chronic obstructive pulmonary disease
• The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion Criteria

• asthma
• has received tracheotomy
• long term mechanical ventilation (which has been accepted for more than 21 days).
• severe pneumonia
• Patients who cannot use a patient with bronchial dilation
• there's a taboo on the use of a sedative.
• refusal to participate in the study
• 48 hours to pull out the tube

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Without atomization inhalation	No drugs	First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group
Atomization inhalation	Salbutamol Aerosol	First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group

Primary Outcome Measures

Name	Time	Method
airway resistance	1 day	The first test of bronchial dilatation
Respiratory mechanics index:PEEPi	1 day

Secondary Outcome Measures

Name	Time	Method
Mechanical ventilation time	28 days
length of hospital stay	30 days
Costs of hospitalization expenses	30 days
Routine blood test:Eosinophilic cells	7days

Trial Locations

Locations (1)

Department of respiratory and critical care medicine,Beijing Chao-yang Hospital; 🇨🇳 Beijing, Beijing, China