Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 发起方
- snow
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Respiratory mechanics index:PEEPi
研究概览
简要总结
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute exacerbation of chronic obstructive pulmonary disease
- •The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours
排除标准
- •has received tracheotomy
- •long term mechanical ventilation (which has been accepted for more than 21 days).
- •severe pneumonia
- •Patients who cannot use a patient with bronchial dilation
- •there's a taboo on the use of a sedative.
- •refusal to participate in the study
- •48 hours to pull out the tube
研究组 & 干预措施
Atomization inhalation
First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group
干预措施: Salbutamol Aerosol (Drug)
Without atomization inhalation
First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group
干预措施: No drugs (Drug)
结局指标
主要结局
Respiratory mechanics index:PEEPi
时间窗: 1 day
airway resistance
时间窗: 1 day
The first test of bronchial dilatation
次要结局
- Mechanical ventilation time(28 days)
- length of hospital stay(30 days)
- Costs of hospitalization expenses(30 days)
- Routine blood test:Eosinophilic cells(7days)