Determination Effective Dose 95 (ED95) of Intravenous Cannulation With the Induction of Sevoflurane 8 Vol% in Patients Aged 1-3 Years Using Dixon up and Down Method
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- ED50 in intravenous cannulation after sevoflurane induction
研究概览
简要总结
This study aimed to determinate effective dose 95 (ED95) intravenous cannulation in pediatric patient after induction of sevoflurane 8 vol%
详细描述
Twenty-two subjects were given informed consent before study enrolled. Anesthesia was induced by 8% sevoflurane with 6 L flow of 100% oxygen. IV cannulation was attempted at 2 min in the first child in each group. The time for cannulation in the next child was stepped up or down by 15 s depending on positive or negative response, respectively, in the previous child. Children were recruited till a minimum of six pairs of failure-success sequence which was obtained in the group. The mean of midpoints of the failure-success sequence was calculated to obtain the time for cannulation in 50% of the group.
研究设计
- 研究类型
- Interventional
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 1 Year 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 1-3 year
- •Physical state ASA I dan II
- •Parents of patients who agreed to participate and sign informed consent.
- •Exclusion criteria:
- •Patients with difficult airway
- •There's allergic reaction or drug's side effect after induction
- •There's cardiorespiratory problem such as anaphylactic shock, aritmia, severe hypotension, desaturation before-on-or after induction
排除标准
- 未提供
结局指标
主要结局
ED50 in intravenous cannulation after sevoflurane induction
时间窗: 2 minutes
using Dixon Up and Down Method
次要结局
未报告次要终点
研究者
Jefferson K Hidayat
MD
Indonesia University