Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes : a Study in Patients With a Thalamic Infarct
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thalamic Infarction
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Performance at the SET (Six Elements Test)
- Last Updated
- 6 years ago
Overview
Brief Summary
The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive behavior. Thus, the project proposes to assess global cognition along with higher-order cognition integrity via sensitive behavior tasks in patients with well localized lesions (mediodorsal thalamic infarcts) compared with healthy participants.
Detailed Description
The recruitment of patients with isolated thalamic lesion after stroke is known to be a challenge that the investigators overcame through the expertise of neurologists within their stroke unit. First, they will describe the cognitive profile consecutive to a lesion of the thalamus, assessed with standardized neuropsychological tests. Second, and more specifically, they will study performances at experimental tasks focusing on higher-order cognition (decision-making, updating, interference managing, multitasking). They will use the automatic localization method already performed : the lesions will be manually segmented from T1 morphologic sequences, and then normalized in a template. Finally a numerical atlas of thalamus will be applied on the lesions, determining the injured substructure and the lesion volume. Besides, this method will be compared with new high resolution thalamus-centered anatomical sequences allowing direct and individual identification of the involved thalamic nucleus.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Performance at the SET (Six Elements Test)
Time Frame: Day 1
Performances of patients with a mediodorsal thalamic infarct in tasks assessing higher order cognition compared to healthy participants. Assessment of multitasking : 6 sub-tasks have to be achieved within 15 minutes. They include arithmetic tasks, image naming tasks, and dictation of a known route. Quantitative scores are derived from quantitative et qualitative data, then interpreted with international normative values.
Secondary Outcomes
- Performances at the PASAT (Pace Auditory Serial Addition Test) updating during working memory(Day 1)
- Performances at the Brown-Petterson task(Day 1)