Spatial Resolution of Pace-Mapping using Automated Template Matching for Site of Origin Identification of Idiopathic Outflow Tract Premature Ventricular Contractions

Recruiting

Conditions: Heart Rhythm Disorder
Ventricular Arrhythmia
10007521

Registration Number: NL-OMON55404

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

- Acceptance for catheter ablation of frequent PVC.
- Pre-procedural 12-lead ECG documentation of PVCs with a suspected site of
-origin in the right or left ventricular outflow tract based on the PVC
morphology (right bundle branch of left bundle branch morphology and inferior
axis)
- Absence of structural heart disease (assessed by echocardiography).

Exclusion Criteria

- Age < 18 years
- Inadequate patient competence
- Pregnancy
- Presence of structural heart disease (e.g., prior myocardial infarction,
non-ischemic cardiomyopathy, infiltrative cardiac disease such as sarcoidosis,
amyloidosis, arrhythmogenic right ventricular cardiomyopathy/dysplasia,
hypertrophic cardiomyopathy, non-compaction cardiomyopathy and congenital heart
disease)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Site of ablation success (RVOT vs LVOT).<br /><br>- Local activation time during PVC at each pacing site<br /><br>- Percentage of pace-match correlation calculated by PASOTM software at each<br /><br>pacing site </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Presence/absence of reversed polarity at the site of ablation success<br /><br>- Secondary endpoint: Ablation success 3 months after the procedure, determined<br /><br>by Holter and defined as a reduction in PVC burden >80% </p><br>