Aminophylline and metoclopramide in pain after vitrectomy

Phase 3

• Conditions: Pain intensity after deep vitrectomy.; Other specified postprocedural states; Z98.89

• Registration Number: IRCT20170716035104N5
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Patients undergoing pars plana deep vitrectomy (20G) surgery
Age between 18 to 75 years
Status classification I or II according to the American Society of Anesthesiologists (ASA) Status Classification System
Body mass index (BMI) less than 35
Ability to speak
Written informed consent

Exclusion Criteria

History of taking corticosteroids and immunosuppressants since one month before surgery
History of allergies to metoclopramide or aminophylline,
Taking metoclopramide, aminophylline, or any other analgesics 24 or less than 24 hours before surgery,
History of malignancy, uncontrolled diabetes, smoking cigarettes, addictive drugs, and alcohol abuse, chronic pain for more than six months, mental illness, evident preoperative anxiety or tachycardia, history of taking anti-anxiety or anti-arrhythmic medications, and a history of general anesthesia by using volatile anesthetics, in the last six months

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient's post-operative pain intensity. Timepoint: At the beginning of admission at the recovery ward, then at 30 and 60 minutes and 2, 4, 8, 16, and 24 hours after entering the recovery ward. Method of measurement: The Visual Analog Scale (VAS).