Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Impaired splenic function in long-term survivors of childhood cancer; diagnostic and therapeutic strategies.

Completed

• Conditions: 10041641; impaired splenic function in long-term survivors of childhood cancer

• Registration Number: NL-OMON47549
• Lead Sponsor: Stichting Kinderoncologie Nederland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 469

Inclusion Criteria

Patients:
Inclusion of all survivors aged >=18 years, after 1) splenectomy, 2)
irradiation over the spleen and 3) total body irradiation

Exclusion Criteria

diagnosis of childhood cancer with survival less than 5 years, age at diagnosis
>17 years or diagnosis while residing in foreign country, survivors who are not
capable of giving informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• Individual diagnostic value of IgM memory B cells after irradiation over the<br /><br>spleen.<br /><br>• The number of hypo- or asplenic patients with vaccine failure.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Duration of protection after pneumococcal vaccination.<br /><br>• The number of survivors with hyposplenism after irradiation over the spleen<br /><br>related to the dose of irradiation and time interval from irradiation assessed<br /><br>by the number of IgM memory B-cells. .</p><br>