Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Hyposalivation in long-term survivors of pediatric cancers following different treatment regiments.
- Conditions
- dry mouthxerostomia10039404
- Registration Number
- NL-OMON47501
- Lead Sponsor
- Stichting Kinderoncologie Nederland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 300
All patients who were treated for childhood cancer (before age 18) in one of
the Pediatric Oncology Centers between 1960 and 2001 and who survived for at
least 5 years after diagnosis will be included in the SKION LATER study.
Participating centres are located in Amsterdam (VU University Medical Center
(VUMC)), Groningen (Children's Cancer Center/ University Medical Center
Groningen (UMCG)), Rotterdam (Rotterdam Erasmus MC-Sophia (REMC-S), Nijmegen
(University Medical Center Nijmegen (UMCN)), Leiden (Leiden University Medical
Center (LUMC) and Utrecht (Princess Máxima Center for Pediatric Oncology
(PMC)). From this cohort, 300 childhood cancer survivors (100 who received
irradiation to head or neck, 100 with a history of chronic graft versus host
disease and 100 treated with chemotherapy but not with radiotherapy) will be
asked to participate in the salivary study
diagnosis of childhood cancer with survival less than 5 years, age at diagnosis
>17 years or diagnosis while residing in foreign country
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- reduced unstimulated and stimulated salivary flow and Patient Reported<br /><br>Outcomes indicative for xerostomia<br /><br>- association between salivary flow measurements and complaints indicative for<br /><br>xerostomia<br /><br>- patient and therapy related risk factors for hyposalivation and xerostomia<br /><br>- association between xerostomia and oral-health-related quality of life<br /><br>- selected microorganisms and markers related to disease, oral function and<br /><br>defense mechanisms in oral fluid samples.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>