Genetic Examination of Patients With Primary Multiple Hernia

• Conditions: Multiple Hernia

• Registration Number: NCT00979095
• Lead Sponsor: Herlev Hospital

Brief Summary

The investigators are performing a genetic study of patients with multiple hernias (at least 3 primary hernias) versus a healthy control group. This genetic information is compared with circulating and subcutaneously biomarkers such as matrix-metalloproteinases (MMP's).

The hypothesis is that patients with multiple hernias have different expression of specific genes compared to the healthy control group.

Detailed Description

Other examinations performed on the patients enrolled in this study:

* Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.

* Beightons score to evaluate the degree of joint hypermobility.

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-09-15
• Study First Submitted QC: 2009-09-16
• Study First Posted: 2009-09-17
• Status Verified: 2010-10
• Last Update Submitted: 2010-10-12
• Last Update Posted: 2010-10-13
• Primary Completion: 2011-06
• Study Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with minimum 3 primary hernias

Exclusion Criteria

• Patients under 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genetic expression of relevant genes between the groups	12 months

Secondary Outcome Measures

Name	Time	Method
Amount of serological biomarkers (MMP's) correlated to gene expression	12 months

Trial Locations

Locations (1)

Jacob Rosenberg; 🇩🇰 Herlev Hospital, Herev, Denmark