Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )Microinfarctions

Recruiting

• Conditions: Acute Cerebral and Cerebellar Cortical Microinfarctions (CMI)
• Interventions: Other: None, purely observational study

• Registration Number: NCT06218576
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Cerebral cortical microinfarctions (CMI) are frequently observed on MRI and histology studies, especially in elderly patients and in patients with cognitive dysfunction. The majority of these studies analysed chronic cerebral CMI lesions.

The few studies reporting on temporal dynamics of MRI signal of acute cerebral CMI showed very low sensibility for persisting signal changes on follow-up MRI on standard MRI sequences. A retrospective study, analysing follow-up 3T MRI in 25 patients with acute cerebral CMI (defined as ≤10 mm on DWI), showed a chronic cerebral CMI detection rate of only 16% on T2-weighted and 5% on FLAIR imaging after a mean follow-up period of 33 months (with a very wide range of 0.5-142 months). Another 3T MRI study including seven patients showed disappearance of all acute cerebral very small-sized CMI (defined as \<5 mm size on initial DWI) on all follow-up MRI sequences (T1- and T2-weighted and FLAIR imaging, performed after one month).

Recently, it has been shown that chronic relatively small (\<20 mm) cerebellar cortical infarctions (based on diffusion-weighted imaging) were frequently observed in acute stroke patients, especially in case of cardioembolic stroke (with chronic small cerebellar cortical infarctions observed in 32% of cases). The high prevalence of these chronic small cerebellar cortical infarctions suggest a possible higher detection rate of chronic small-sized infarction in the cerebellum compared to the supratentorial brain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-01-12
• Study First Submitted QC: 2024-01-12
• Study First Posted: 2024-01-23
• Study Start: 2024-02-15
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-28
• Last Update Posted: 2024-03-29
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

Patients admitted to our stroke centre between February 2021 and June 2023 with the following inclusion criteria:

• age >18 years,
• initial MRI performed within one week after symptom onset,
• symptomatic brain infarction confirmed by DWI,
• presence of acute cerebral and/or cerebellar CMI

Exclusion Criteria

• age < 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
acute cerebral and/or cerebellar CMI	None, purely observational study	Patients with acute cerebral and/or cerebellar CMI

Primary Outcome Measures

Name	Time	Method
Chronic CMI	6 monthes	Detection rate of chronic CMI on follow-up MRI used in daily clinical practice after initial acute cerebral and cerebellar CMI (≤10 mm) (Nb)
CMI localisations	6 monthes	Compare initial acute cerebral and cerebellar CMI (≤10 mm) localisation (cerebral or cerebellar)

Trial Locations

Locations (1)

CHU de Nîmes; 🇫🇷 Nîmes, France