Whole fruit and medolla powder of Elaeagnus angustifolia effect on osteoarthritis
Phase 3
- Conditions
- knee osteoarthritis.Bilateral primary osteoarthritis of knee
- Registration Number
- IRCT201208241197N13
- Lead Sponsor
- Vice chancellor for research, Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
1.Female
2.Age: 40-70 years
3.Bilateral primary osteoarthritis of knee (according to ACR classification)
4.Body mass index of 25-29.9
Exclusion criteria:
1.Secondary osteoarthritis
2.Active synovitis
3.Neurological disorder that affects movement, muscle control and balance
4.Uncontrolled hypertension, diabetes, cardiovascular disorders, chronic kidney disorders and functional liver disorders
5.Using Frosemid, Probenecid, Anticoagulants, Hydantoin, Sulfonamides, Methotrexate, Lithium salts, Beta blockers and muscle relaxants
6.Smoking
7.Having an allergic reaction to Elaeagnus angustifolia
8. Daily use of Elaeagnus Angustifolia
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Onset and after the study. Method of measurement: WOMAC questionnaire.;Joint stiffness. Timepoint: Onset and after the study. Method of measurement: WOMAC questionnaire.;Disability. Timepoint: Onset and after the study. Method of measurement: WOMAC questionnaire.
- Secondary Outcome Measures
Name Time Method Plasma total antioxidant capacity and MDA level. Timepoint: Onset and at the end of the study. Method of measurement: Antioxidant capacity = Randox kit, MDA= Fluorometry.;Serum IL-1, IL-10 and TNF-alpha levels. Timepoint: Onset and at the end of the study. Method of measurement: IL-1:ELISA kit; IL-10:ELISA kit; TNF-alpha: ELISA kit.;Serum MMP-1 and MMP-13 levels. Timepoint: Onset and at the end of the study. Method of measurement: MMP-1:ELISA kits; MMP-13:ELISA kit.;Nutritional status and dietary intake. Timepoint: Onset and at the end of the study. Method of measurement: Dietary intake: 24 hours questionnaires; Nutritional status: Weight: Standard scale, Height: Stadiometer.