Influence of Mannose-Binding Lectin Polymorphisms on Infectious Complications in Trauma Patients

Completed

• Conditions: MBL-deficiency; suboptimal immune status; 10040792

• Registration Number: NL-OMON30944
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 450

Inclusion Criteria

Trauma patients with an ISS of 16 or higher
Age between 18 and 70 years
Compos mentis
Informed consent

Exclusion Criteria

ISS<16
Age <18 or >70 years
Death within 24 hours after the trauma
No informed consent
Patients with a known immune disorder
Use of immunosuppressive drugs

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Bacteremia (BSI)<br /><br>Pneumonia<br /><br>Systemic Inflammatory Response Syndrome (SIRS)<br /><br>Sepsis<br /><br>Septic shock</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Death within 3 months<br /><br>Surgical site infection<br /><br>Osteitis after osteosynthesis of fractures</p><br>