Invloed van Mannose-Binding Lectin Polymorfismen op Infectieuze Complicaties bij Traumapatiënten.

Completed

• Conditions: Polytrauma; trauma with injury severity score > 15 points

• Registration Number: NL-OMON27107
• Lead Sponsor: Erasmus MC

Brief Summary

Bronkhorst MWGA, Boyé NDA, Lomax MAZ, Vossen RHAM, Bakker J, Patka P, Van Lieshout EMM. Single Nucleotide Polymorphisms in the Toll-Like Receptor Pathway increase Susceptibility to Infections in Severely Injured Trauma Patients. J Trauma Acute Care Surg 2013 Mar;74(3):862-870. <br><br> Bronkhorst MWGA, Lomax MAZ, Vossen RHAM, Bakker J, Patka P, Van Lieshout EMM. Risk of infection and sepsis in severely injured patients related to single nucleotide polymorphisms in the lectin pathway. Br J Surg. 2013 Dec;100(13):1818-26.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 450

Inclusion Criteria

1. Trauma patients with an ISS of 16 or higher:

2. Age between 18 and 70 years;

Exclusion Criteria

1. ISS<16;

2. Age <18 or >70 years;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Bacteremia (BSI);<br /><br>2. Pneumonia;<br /><br>3. Systemic Inflammatory Response Syndrome (SIRS);<br /><br>4. Sepsis;<br /><br>5. Septic shock.

Secondary Outcome Measures

Name	Time	Method
1. Death within 3 months;<br /><br>2. Surgical site infection;<br /><br>3. Osteitis after osteosynthesis of fractures.