A comparison between different strategies to handle anticoagulation during cardiac surgery
Not Applicable
Completed
- Conditions
- Study anticoagulation strategies during cardiopulmonary bypass.Circulatory System
- Registration Number
- ISRCTN14201041
- Lead Sponsor
- Sahlgrenska University Hospital
- Brief Summary
2015 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26134993 results
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. Patients undergoing elective coronary artery bypass grafting surgery or single valve repair/replacement on cardiopulmonary bypass
2. >18 years old
Exclusion Criteria
1. Acute operation
2. Known bleeding disorder, liver or kidney disease,
3. Previous stroke
4. Treatment with a P2Y12 receptor antagonist <5 days before surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endogenous thrombin potential in plasma 2 hours after surgery as assessed by calibrated automated thrombogram.
- Secondary Outcome Measures
Name Time Method <br> 1. Total heparin and protamine doses during the operation<br> 2. Whole blood clot formation as measured with thromboelastometry 10 min, 2h and 4h after the operation<br> 3. Hemostatic analyses (aPTT, PT, anti-thrombin, fibrinogen, platelet count) 10 min, 2h and 4h after the operation<br> 4. Postoperative bleeding volume the first 12 h, Red blood cell transfusion during hospital stay<br>