Serotonine in cocaine dependence: towards novel diagnostic markers for addicts responsive to behavioural-cognitive therapy

Conditions: verslaving
cocaine addiction

Registration Number: NL-OMON36394

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

Male subjects with cocaine dependence as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV; American Psychiatric Association 1994), and will be determined by a structured interview (Composite International Diagnostic Interview: CIDI) aged 18-40 years.
Controls: male healthy volunteers aged 18-40 years.

Exclusion Criteria

No cocaine dependence
Positive DSM-IV/CIDI for any drug other than cocaine, heroin, alcohol or marijuana
Major neurological disorders, claustrophobia, peripheral vascular diseases, current use of respiratory, cardiovascular, anticonvulsant or psychoactive medications (SSRIs), or alexithymia
A positive urine test result for amphetamines, barbiturates, benzodiazepine metabolites, cocaine (metabolite), opiates, alcohol, and marijuana

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Vigilance level (an fMRI task): % BOLD signal change in the ventral<br /><br>frontostriatal circuit (which is associated with reversal learning).<br /><br>- 5HTT function (a phMRI study): peak amplitude (maximum % change relative to<br /><br>baseline) in cerebral blood flow (CBF) evoked by an acute pharmacological<br /><br>challenge with citalopram. </p><br>

Secondary Outcome Measures