A Novel Therapy for cocaine dependence during abstinence: A randomized clinical trial

Phase 1

• Conditions: The inclusion criteria for participation in this study were: 1) having the respective age between 18 and 31, 2) History of one months of cocaine avoidance, and 3) having at least the educational level; Topiramate, Contingency Management, Craving, Anticonvulsants/adverse effects, Pharmacotherapy, Cocaine Dependence

• Registration Number: TCTR20170112001
• Lead Sponsor: non

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-01-01
• Study Start: 2017-01-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Terminated (Halted Prematurely)
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

The inclusion criteria for participation in this study were: 1) having the respective age between 18 and 31, 2) History of one months of cocaine avoidance, and 3) having at least the educational level of Diploma.

Exclusion Criteria

Also the exclusion criteria were: 1) Report of positive urine test during remedial period, 2) Taking supplementary drug and psychological remedies, and 3) three continuous weeks of absence from participation in remedial meetings.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The results showed that all three types of treatment played a efficacy in reducing the craving 12-week ANCOVA Univariate Model ,scores of craving was 12.04 with TPM, 13.89 with CM, 10.92 with Mix (p = 0.01) and 16.89 in control 12-week ANCOVA Univariate Model

Secondary Outcome Measures

Name	Time	Method
The highest variance explaining the changes in craving was assigned to the combined mix treatment. 12-week Scheffe’s post hoc