Innovative approaches for cocaine pharmacotherapy using fMRI: The case of varenicline
- Conditions
- verslavingcocaine addictiondrug dependence
- Registration Number
- NL-OMON33821
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
1. male, aged 18-60 years;
2. current DSM-IV diagnosis of cocaine dependence, but recently detoxified and abstinent;
3. able to provide written informed consent and to comply with all study procedures.
1. Currently dependent on any substance other than cocaine or nicotine;
2. History of depression that could be defined as even a single episode or recurrent episodes of depression, or depression necessitating hospitalization, or history of suicide attempt;
3. Severe neurological or psychiatric disorders (e.g., psychosis, bipolar illness, dementia, or any diseases that require psychotropic medications);
4. Serious medical illnesses;
5. Known hypersensitivity or allergy to varenicline, or receiving chronic therapy with medication that could interact adversely with one of the medications under study, within 30 days prior to randomization;
6. Drugs known to influence binding to DA2 receptors, including neuroleptics, and methylphenidate;
7. Received a drug with known potential for toxicity to a major organ system within the month prior to entering treatment;
8. Clinically significant abnormal laboratory values, as measured by the treatment centre;
9. Any disease of the gastrointestinal system, liver, or kidneys which could result in altered metabolism or excretion of the study medication.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Craving and impulsivity.<br /><br>Research assesing the respons towards cocaine-associated cues.<br /><br><br /><br>Varenicline may reduce craving to cocaine and/or impulsivity in human cocaine<br /><br>users.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>