se of Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure.
Not Applicable
- Conditions
- Health Condition 1: K769- Liver disease, unspecified
- Registration Number
- CTRI/2023/10/058417
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients of ACLF as per APASL criteria between 18 to 70 years of age
2.Patient and attendants willing to give informed consent
Exclusion Criteria
1.Age <18 years and > 70 years
2.Survival less than 7 days
3.Cirrhosis with prior decompensation
4.Grade 3 ascites
5.Hepatic encephalopathy grade III &IV
6.HCC/SOL >2cm in liver
7.Patient with congestive heart failure
8.Patient with extrahepatic cholestasis
9.Portal vein thrombosis
10.BMI >30 kg/m2
11.Prior variceal endotherapy or ongoing beta blocker treatment for varices
12.Pregnant and lactating women
13.Patient with cardiac pacemaker
14.Critically ill patients
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute changes in liver and splenic stiffness on day 7 in patients of ACLF predicts liver transplant free <br/ ><br>survival at 3 months <br/ ><br>Timepoint: 3 months
- Secondary Outcome Measures
Name Time Method Acute changes in liver and splenic stiffness on day 14 in patients of ACLF predicts liver transplant free survival at 3 monthsTimepoint: 3 months;Association of baseline and change in liver and splenic stiffness with etiology of ACLFTimepoint: Day 14;Association of baseline and change in liver and splenic stiffness with pattern of organ failuresTimepoint: Day 14;Association of baseline liver and splenic stiffness with grade of esophageal varices in ACLF patientsTimepoint: 1-7 days;Association of baseline liver and splenic stiffness with severity of ACLF by AARC-ACLF score, CLIF-C-ACLF score, MELD-Na and CTP at presentationTimepoint: Day 1;Association of change in liver and splenic stiffness with change in AARC-ACLF score and CLIF-C-ACLF score.Timepoint: Day 14;Association of changes in level of biochemical inflammatory markers with change in liver and splenic stiffness.Timepoint: Day 14