Predictors of acute liver failure and death from patients with dengue-induced severe hepatitis

Not Applicable

Completed

• Conditions: Sorology- confirmed of dengue infection with acute liver failure; Dengue; Liver failure; Severe hepatitis; Mortality; Prognosis; Predictive factor

• Registration Number: TCTR20200404003
• Lead Sponsor: one

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-11-01
• Study Start: 2020-04-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 151

Inclusion Criteria

(1) Age > 10 years; (2) Dengue infection and classification were defined according to the WHO criteria7 with serological confirmation by the detection of dengue immunoglobulin M antibody or nonstructural 1 antigen; (3) Blood tests for serum glutamate-oxaloacetate transaminase (SGOT) > 350 U/L or serum glutamate-pyruvate transaminase (SGPT) > 400 U/L within 24 hours after hospital admission.

Exclusion Criteria

(1) Liver biochemistries was not performed within 7 days after the onset of fever; (2) Incomplete clinical information; and (3) Having concomitant cause of liver injury, such as the use of acetaminophen with dose over 150 mg/kg within the recent 96 hours; a prior consumption of > 40 (female) or > 60 (male) gram of alcohol/day within the recent 60 days.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute liver failure from dengue infection 28 days Observation

Secondary Outcome Measures

Name	Time	Method
Mortality 30 days Observation